GONADOTROPIN RELEASING ACTIVITY IN RAT HYPOTHALAMIC EXTRACT
スポンサーリンク
概要
- 論文の詳細を見る
Anterior pituitary glands from normal female rats were cultivated by the organ culture method in an attempt to investigate whether extract of the rat hypothalamus may stimulate the glands directly to release FSH, LH or both. Hypothalamic tissues of mature female rats were extracted with 1.0<I>M</I> acetic acid. FSH-RF or LHRF activity of the extract was determined by estimating FSH or LH activity of cultures treated with the extract. FSH activity was measured by the method of Steelman-Pohley, and LH activity was done by the method of Parlow. The extract could stimulate the release of signifocant amounts of LH, whereas brain cortical extract, oxytocin and lysine-vasopressin were inactive. Contamination of LH in the extract was denied. The results provide evidence for the presence of an LH-RF in the rat hypothalamus. On the other hand, whether there is an FSH-RF in the rat hypothalamus needs to be further investigated. Autoradiography of cultivated glands demonstrated that the hypothalamic extract increased the uptake of <SUP>3</SUP>H-leucine by PAS-positive cells, indicating that the action of the extract is probably related to the synthesis of gonadotropin.
- 社団法人 日本内分泌学会の論文
著者
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Mizuno Masahiko
Department Of Neurosurgery And Pediatrics Kansai Medical School
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Kigawa Tomonori
Department Of Obstetrics And Gynecology Faculty Of Medicine University Of Tokyo Tokyo
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Kobayashi Takuro
Department Of Dermatology Field Of Sensory Organology Kagoshima University Graduate School Of Medica
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KOBAYASHI Takashi
Department of Applied Physics,Faculty of Engineering,Nagoya University
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AMENOMORI YOSHIHIKO
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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WATANABE TAKU
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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