ELECTRON MICROSCOPIC OBSERVATION ON THE HYPOTHALAMOHYPOPHYSEAL SYSTEM IN THE RAT:III. EFFECT OF RESERPINE TREATMENT ON THE AXONAL INCLUSIONS IN THE MEDIAN EMINENCE

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The ultrastructural alterations of the median eminence after treatment with reserpine were observed with particular references to the axonal inclusions. The electron-dense large granules (mean diameter: 156mμ), which were present exclusively in the nerve fibres of the internal layer, increased slightly in number after treatment with reserpine. These granules are thought to be the carriers of neurohypophyseal hormones. The electron-dense middle-sized granules (mean diameter: about 110mμ), which were present abundantly in the axons of the external layer and in less number in the internal layer, were little influenced by treatment with 10mg/kg of reserpine. With 20mg/kg, however, the granules decreased in relative number. The nature and functional significance of these granules are unknown. The electron-dense small granules (mean diameter: about 80mμ), which were abundantly observed in the perivascular nerve endings of the external layer (contact region) decreased remarkably in number after reserpine treatment. From several points these small granules are thought to be the carriers of catecholamines. The small vesicles with diameter of 40-80mμ, found in the nerve fibres of the external and of the internal layer of the median eminence, increased significantly in number after reserpine treatment. The nature and origin of these small vesicles will be discussed.
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