Utilization of Knockout Mice to Examine the Potential Role of Gastric Histamine H_2-Receptors in Menetrier's Disease

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概要

• 論文の詳細を見る

• Menetriers disease is characterized by giant gastric folds with foveolar hyperplasia and cystic dilatation, hypoproteinemia, and enhanced mucus secretion. The etiology remains unresolved and an effective treatment has yet to be established. Here we show that histamine H2-receptor deficient mice developed gastric pathophysiological changes resembling Menetriers disease for up to 17 months of observation. Mutant mice were found to have an increased stomach weight, enlarged gastric folds with cystic dilatation, hypergastrinemia, hypoalbuminemia, increased mucus secretion and overexpression of mucosal transforming growth factor (TGF) α. Both a cholecystokinin (CCK)2-receptor antagonist and an epidermal growth factor (EGF)-receptor tyrosine kinase inhibitor significantly reduced the increase in stomach weight. It appears that lack or downregulation of histamine H2-receptors might be involved in the pathogenesis of Menetriers disease.

• 社団法人 日本薬理学会の論文
• 2003-01-01

著者

• KOBAYASHI Takashi

  Department of Information Engineering, Graduate School of Information Science, Nagoya University

• Kobayashi Takashi

  Department Of Cardiology Kobe City Medical Center General Hospital

• WATANABE Takeshi

  Department of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University

• Ogawa Toshiki

  京都薬科大学 応用薬理

• Ogawa Toshiki

  Department Of Applied Pharmacology Kyoto Pharmaceutical University

• MAEDA Kazuhiko

  Department of Chemical System Engineering, School of Engineering, The University of Tokyo

• TONAI Shunsuke

  Department of Applied Pharmacology, Kyoto Pharmaceutical University

• OKABE Susumu

  Department of Applied Pharmacology, Kyoto Pharmaceutical University

• Okabe S

  Department Of Applied Pharmacology Kyoto Pharmaceutical University

• Okabe Susumu

  Department Of Applied Pharmacology Kyoto College Of Pharmacy

• Tonai Shunsuke

  Department Of Applied Pharmacology Kyoto Pharmaceutical University

• Watanabe Takeshi

  Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University

• Maeda Kazuhiko

  Department Of Applied Pharmacology Kyoto Pharmaceutical University

• Maeda Kazuhiko

  Department Of Applied Chemistry Faculty Of Engineering Miyazaki University

• Watanabe T

  Department Of Molecular Immunology Medical Institute Of Bioregulation Kyusyu University

• Watanabe Takeshi

  Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University

• Kobayashi Takashi

  Department Of Molecular Immunology Medical Institute Of Bioregulation Kyusyu University

• Kobayashi Takashi

  Department Of Biology Faculty Of Science Kanazawa University

• KOBAYASHI Takashi

  Department of Applied Physics,Faculty of Engineering,Nagoya University

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