Effect of Gefarnate on Acute Gastric Mucosal Lesion Progression in Rats Treated with Compound 48/80, a Mast Cell Degranulator, in Comparison with That of Teprenone(Pharmacology)

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概要

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• We have reported that teprenone (geranylgeranylacetone), an anti-ulcer drug, prevents acute gastric mucosal lesion progression in rats treated once with compound 48/80 (C48/80), a mast cell degranulator, possibly by suppressing mucus depletion, neutrophil infiltration, and oxidative stress in the gastric mucosa. Herein, we examined the preventive effect of gefarnate (geranyl farnesylacetate), an anti-ulcer drug, on acute gastric mucosal lesion progression in rats treated once with C48/80 (0.75mg/kg, i.p.) in comparison with that of teprenone, because the chemical structure and anti-ulcer action of gefarnate are similar to those of teprenone. Gefarnate (50, 100 or 200mg/kg) administered orally at 0.5 h after C48/80 treatment, at which time gastric mucosal lesions appeared, reduced progressive gastric mucosal lesions at 3 h dose-dependently. At 3 h after C48/80 treatment, the gastric mucosa had decreased adherent mucus and hexosamine contents and increased myeloperoxdiase (an index of neutrophil infiltration) and xanthine oxidase activities and thiobarbituric acid reactive substances (an index of lipid peroxidation) content. Post-administered gefarnate attenuated all these changes dose-dependently. These preventive effects of gefarnate were similar to those of teprenone at a dose of 200mg/kg. Post-administered gefarnate did not affect the increases in serum serotonin and histamine concentrations and the decrease in gastric mucosal blood flow at 3 h after C48/80 treatment like teprenone. These results indicate that orally administered gefarnate prevents acute gastric mucosal lesion progression in C48/80-treated rats possibly by suppressing mucus depletion, neutrophil infiltration, and oxidative stress in the gastric mucosa like teprenone.

• 2005-08-01

著者

• KOBAYASHI Takashi

  Department of Information Engineering, Graduate School of Information Science, Nagoya University

• Kobayashi Takashi

  Department Of Cardiology Kobe City Medical Center General Hospital

• NAKAZAWA Saburo

  Department of Internal Medicine, Fujita Health University School of Medicine

• OHTA Yoshiji

  Department of Chemistry, Fujita Health University School of Medicine

• 今井 淑夫

  Division Of Pathology National Institute Of Health Sciences

• 今井 淑夫

  東京工業大学部有機材科工学科

• Yoshino Junji

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• 今井 淑夫

  元 東京工業大学工学部有機材料工学科

• Imai Yoichiro

  Department Of Clinical Biochemistry Fujita Health University College

• INUI Kazuo

  Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health Univers

• Ohta Yoshiji

  Department Of Biochemistry School Of Medicine Fujita Health University

• Nakazawa Saburo

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• Inui Kazuo

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• Inui Kazuo

  Department Of Internal Medicine Fujita Health University School Of Medicine Second Teaching Hospital

• 今井 淑夫

  東京工業大学

• Nakazawa Saburo

  Department Of Gastroenterology Yamashita Hospital

• Yoshino Junji

  Department Of Internal Medicine Second Teaching Hospital Fujita Health University School Of Medicine

• Kobayashi Takashi

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• Ohta Yoshiji

  藤田保健衛生大学 医学部化学教室

• KOBAYASHI Takashi

  Department of Applied Physics,Faculty of Engineering,Nagoya University

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