Protective Effect of Ebselen, a Seleno-Organic Compound, Against the Progression of Acute Gastric Mucosal Lesions Induced by Compound 48/80, a Mast Cell Degranulator, in Rats

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概要

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• The protective effect of ebselen, which possesses glutathione peroxidase-like activity and antioxidative and anti-inflammatory properties, against the progression of acute gastric mucosal lesions was examined in rats with a single intraperitoneal injection of compound 48/80 (0.75 mg/kg). Ebselen (50, 100 or 200 mg/kg) was orally administered 0.5 h after compound 48/80 treatment, at which time gastric mucosal lesions appeared. Post-administered ebselen suppressed gastric mucosal lesion progression at 3 h after compound 48/80 treatment dose-dependently, although no dose of ebselen affected the decreased gastric mucosal blood flow and increased serum serotonin and histamine concentrations found at 3 h after the treatment. A decrease in Se-glutathione peroxidase activity and increases in myeloperoxidase and xanthine oxidase activities and the concentration of thiobarbituric acid reactive substances were found in gastric mucosal tissues at 0.5 h after compound 48/80 treatment, and these changes were further enhanced at 3 h. Post-administered ebselen attenuated all these changes found at 3 h after compound 48/80 treatment dose-dependently. The present results indicate that ebselen exerts a protective effect against the progression of compound 48/80-induced acute gastric mucosal lesions in rats, and they suggest that this protective effect of ebselen could be due to its glutathione peroxidase-like activity and its antioxidative and anti-inflammatory properties.

• 社団法人 日本薬理学会の論文
• 2002-12-01

著者

• KOBAYASHI Takashi

  Department of Information Engineering, Graduate School of Information Science, Nagoya University

• Kobayashi Takashi

  Department Of Cardiology Kobe City Medical Center General Hospital

• NAKAZAWA Saburo

  Department of Internal Medicine, Fujita Health University School of Medicine

• OHTA Yoshiji

  Department of Chemistry, Fujita Health University School of Medicine

• Yoshino Junji

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• INUI Kazuo

  Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health Univers

• Ohta Yoshiji

  Department Of Biochemistry School Of Medicine Fujita Health University

• Nakazawa Saburo

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• YOSIHNO Junji

  Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health Univers

• Inui Kazuo

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• Inui Kazuo

  Department Of Internal Medicine Fujita Health University School Of Medicine Second Teaching Hospital

• Nakazawa Saburo

  Department Of Gastroenterology Yamashita Hospital

• Kobayashi Takashi

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• Ohta Yoshiji

  藤田保健衛生大学 医学部化学教室

• KOBAYASHI Takashi

  Department of Applied Physics,Faculty of Engineering,Nagoya University

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