Action of Aspirin on Whole Blood-Aggregation Evaluated by the Screen Filtration Pressure Method
スポンサーリンク
概要
- 論文の詳細を見る
Background There are few monitoring systems widely used in clinical practice for evaluating the effectiveness of aspirin therapy, so in the present study aspirin's antiplatelet effects we investigated with a whole blood aggregometer using a screen filtration pressure (SFP) method. Methods and Results Thirty-five healthy male volunteers took 100mg/day aspirin for 14 days. Whole-blood aggregation was analyzed at baseline and on days 7 and 14, using collagen and adenosine diphosphate as the stimuli, and compared with the platelet-rich plasma (PRP) aggregation measured by optical aggregometer. The platelet-aggregation threshold index (PATI) for both methods, which was defined as the putative agonist-concentration giving half-maximal aggregation, and the PRP-maximal aggregation rate were analyzed. The maximal aggregation rate induced by 1.6mg/L collagen decreased from 85.5% (80.8-92.8) [median (interquartile range)] at baseline to 51.5% (39-63.8) on day 14 (p<0.0001). The PRP-PATI and whole-blood PATI for collagen in-creased from 0.32 (0.28-0.70) to 1.82mg/L (1.25-2.89) (p<0.0001) and from 0.28 (0.22-0.3) to 1.06mg/L (1.01-1.29) (p<0.0001) respectively. Conclusions The whole-blood PATI and PRP-PATI for collagen, as well as the maximal PRP aggregation rate, clearly distinguish platelet aggregability before and after aspirin intake. However, whole-blood analysis by the SFP-method is easier to perform, and is a promising method of monitoring aspirin's effects.
- 社団法人日本循環器学会の論文
- 2008-02-20
著者
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MORIMOTO Takeshi
Department of Ophthalmology, Osaka University Medical School
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Kawato Mitsunori
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Mitsudo Kazuaki
Department Of Cardiology Himeji Cardiovascular Center
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TABUCHI Arata
Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University
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Taniguchi Ryoji
Cardiovascular Medicine, Kyoto University
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Takahashi Kanako
Cardiovascular Medicine, Kyoto University
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Kondo Hirokazu
Cardiovascular Medicine, Kyoto University
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Kawato Mitsunori
Cardiovascular Medicine, Kyoto University
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Kimura Takeshi
Cardiovascular Medicine, Kyoto University
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Kita Toru
Cardiovascular Medicine, Kyoto University
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Horiuchi Hisanori
Cardiovascular Medicine, Kyoto University
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Kobayashi Takashi
Department Of Cardiology Kobe City Medical Center General Hospital
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Mitsudo Kazuaki
Department Of Cardiovascular Medicine Kyoto University
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TABUCHI Arata
Geriatric Medicine, Graduate School of Medicine, Kyoto University
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Kawato Mitsunori
Department Of Cardiovascular Medicine Kyoto University
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Mitsudo Kazuaki
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Kida Mitsugu
Division Of Cardiology Kurashiki Central Hospital
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Kondou Hirokazu
Department Of Cardiovascular Medicine Kyoto University
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Tabuchi Arata
Department Of Cardiology Kokura Memorial Hospital
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Tabuchi Arata
Geriatric Medicine Graduate School Of Medicine Kyoto University
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Morimoto Takeshi
Department Of Applied Visual Science Graduate School Of Medicine
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Taniguchi Ryoji
Department Of Cardiovascular Medicine Kyoto University
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Taniguchi Ryoji
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Kinugasa Mitsuo
Department Of Cardiovascular Medicine Kyoto University
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Kondo Hirokazu
Cardiovascular Center Osaka Red Cross Hospital
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Horiuchi Hisanori
Department Of Cardiovascular Medicine Kyoto University
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Horiuchi Hisanori
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Minami Kazuaki
Department Of Cardiology Other Hospitals
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Misumi Kazuo
Department Of Cardiology Other Hospitals
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Higuchi Hirokazu
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Kimura Takeshi
Cardiovascular Center Yokosuka Kyosai Hospital
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