Effect of Oral Vitamin E Administration on Acute Gastric Mucosal Lesion Progression in Rats Treated with Compound 48/80, a Mast Cell Degranulator(Pharmacology)

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概要

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• The effect of oral vitamin E administration on acute gastric mucosal lesion progression was examined in rats treated once with compound 48/80 (C48/80) (0.75 mg/kg, i.p.) in comparison with that of subcutaneously administered superoxide dismutase (SOD) plus catalase (CAT). Vitamin E (50, 100 or 250mg/kg) administered at 0.5h after C48/80 treatment reduced progressive gastric mucosal lesions at 3h after the treatment dose-dependently, like SOD plus CAT administered at the same time point. The gastric mucosa of C48/80-treated rats had decreased Se-glutathione peroxidase activity and vitamin E, ascorbic acid, and hexosamine contents and increased myeloperoxidase and xanthine oxidase activities and thiobarbituric acid reactive substances content at 3h after the treatment. Administered vitamin E attenuated all these changes found at 3h after C48/80 treatment dose-dependently, like administered SOD plus CAT. C48/80-treated rats administered with vitamin E (100 or 250mg/kg) had higher gastric mucosal vitamin E content than C48/80-untreated rats. Neither administered vitamin E nor SOD plus CAT had any effect on the increases in serum serotonin and histamine concentrations and the decrease in gastric mucosal blood flow found at 3h after C48/80 treatment. In the gastric mucosa of C48/80-untreated rats administered with vitamin E, thiobarbituric acid reactive substances content decreased with an increase in vitamin E content. These results indicate that orally administered vitamin E prevents acute gastric mucosal lesion progression in C48/80-treated rats possibly by suppressing oxidative stress, neutrophil infiltration, and mucus depletion in the gastric mucosa like administered SOD plus CAT.

• 2006-04-01

著者

• KOBAYASHI Takashi

  Department of Information Engineering, Graduate School of Information Science, Nagoya University

• Kobayashi Takashi

  Department Of Cardiology Kobe City Medical Center General Hospital

• NAKAZAWA Saburo

  Department of Internal Medicine, Fujita Health University School of Medicine

• OHTA Yoshiji

  Department of Chemistry, Fujita Health University School of Medicine

• 今井 淑夫

  Division Of Pathology National Institute Of Health Sciences

• 今井 淑夫

  東京工業大学部有機材科工学科

• Yoshino Junji

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• 今井 淑夫

  元 東京工業大学工学部有機材料工学科

• Imai Yoichiro

  Department Of Clinical Biochemistry Fujita Health University College

• INUI Kazuo

  Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health Univers

• Ohta Yoshiji

  Department Of Biochemistry School Of Medicine Fujita Health University

• Nakazawa Saburo

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• Inui Kazuo

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• Inui Kazuo

  Department Of Internal Medicine Fujita Health University School Of Medicine Second Teaching Hospital

• 今井 淑夫

  東京工業大学

• Nakazawa Saburo

  Department Of Gastroenterology Yamashita Hospital

• Yoshino Junji

  Department Of Internal Medicine Second Teaching Hospital Fujita Health University School Of Medicine

• Kobayashi Takashi

  Department Of Internal Medicine Second Teaching Hospital School Of Medicine Fujita Health University

• Ohta Yoshiji

  藤田保健衛生大学 医学部化学教室

• KOBAYASHI Takashi

  Department of Applied Physics,Faculty of Engineering,Nagoya University

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