ELECTROPHYSIOLOGICAL STUDIES ON THE FEED-BACK MECHANISM OF PROGESTERONE
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概要
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To clarify the functional relation between the ovulation blocking-effect and the central depresant action of progesterone, electrophysiological studies were done, using unanesthetized curarized albino rats under artificial respiration, additionally using rabbits and cats, and the following results were obtained:<BR>(1) After the administration of progesterone (10-20mg/kg), EEG of the hippocampus and neocortex showed sleep patterns, lasting 1 hr.<BR>(2) Activation threshold of posterior hypothalamic stimulation upon the hippocampus and neocortex was markedly elevated after the administration of progesterone.<BR>(3) The threshold voltage of desynchronizing the hippocampal regular slow waves by anterior hypothalamic stimulation remained almost unchanged.<BR>(4) The threshold voltage of the recruiting response of the neocortex by stimulation of nucleus centrum medianum almost unchanged.<BR>From these results it is concluded that progesterone seems to suppress the activity level of the posterior hypothalamus as well as that of the limbic-midbrain area (Nauta, 1958) by which the blockade of ovulation may take place.
- 社団法人 日本内分泌学会の論文
著者
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Kawamura Hiroshi
Second Department Of Internal Medicine Nihon University School Of Medicine.
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Oshima Kiyoshi
Department Of Otolaryngology University Of Tokyo
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Kobayashi Takuro
Department Of Dermatology Field Of Sensory Organology Kagoshima University Graduate School Of Medica
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Kobayashi T.
Department Of Internal Medicine Tokyo University Branch Hospital
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KOBAYASHI TAKASHI
Department of Obstetrics and Gynecology, School of Medicine, University of Tokyo
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TAKEZAWA SHIZUMA
Department of Obstetrics and Gynecology, School of Medicine, University of Tokyo
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KOBAYASHI TAKURO
Department of Obstetrics and Gynecology, School of Medicine, University of Tokyo
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KAWAMURA HIROSHI
Second Department of Physiology, School of Medicine, Yokohama University
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