STUDIES ON THE RISK FACTORS OF INTRAUTERINE INFECTION OF HEPATITIS B VIRUS
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概要
- 論文の詳細を見る
B型肝炎ウイルス(HBV)の胎内感染に関する機序を解明する目的で,22例のHBe抗原陽性のキャリア妊婦とその児について以下の検討を行つた.22例の新生児のうち,3例は胎内感染例であつた.残りの19例は,HBIGとHBワクチンの投与により,母児感染の予防に成功した. HBV胎内感染に関連するリスク因子として,1)母体の肝機能異常,2)母体血の高いHBs抗原価,HBe抗原価,またはHBV-DNA量,3)臍帯血のHBe抗原価について検討したが,いずれにも胎内感染との関連性は認められなかつた.一方,これらのうち,4例に妊娠中に著明な切迫流早産徴候がみられた.そのうちの2例は,満期に分娩となつたが,胎内で感染していたことが判明した.残りの2例は,切迫早産徴候の発生から1週間以内に早産となつたが,臍帯血中にHBs抗原が検出されなかつたために,HBIGが投与され,結果的には感染の予防に成功した. 以上のことから,切迫流早産で代表される子宮の収縮によつて母体血が胎盤を通して胎児へ移行する可能性があり,そのことがHBVの胎内感染の機序と深く関連しているのではないかと考えられた.また,母児間の血液移行がおきても,1週間以内にHBIGを投与すれば,感染が予防できる可能性のあることも示された.
- 社団法人日本産科婦人科学会の論文
- 1985-11-01
著者
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YONEYAMA Tetsuo
Department of Virology II, National Institute of Infectious Diseases
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Yoneyama Tetsuo
Department Of Enterovirus National Institute Of Health Tokyo
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KAWANO Takashi
Department of Applied Physics, Faculty of Engineering, Osaka University
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Etoh Takashi
Department Of Pediatrics Faculty Of Medicine University Of Tokyo Tokyo
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MIZUNO Masahiko
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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HSIUNG Lin
Department of Obstetrics and Gynecology, Blood Transfusion Service,
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OHTO Hiroshi
Blood Transfusion Service
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Mizuno Masahiko
Department Of Obstetrics And Gynecology Faculty Of Medicine University Of Tokyo
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Kawano Takashi
Department Of Obstetrics And Gynecology Blood Transfusion Service
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Kawano Takashi
Department Of Anesthesiology Tokushima University School Of Medicine
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Mizuno Masahiko
Department Of Neurosurgery And Pediatrics Kansai Medical School
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Hsiung Lin
Department Of Obstetrics And Gynecology Blood Transfusion Service
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Mizuno Masahiko
Department Of Obstetrics And Gynecology Blood Transfusion Service
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Kawano Takashi
Department Of Anesthesiology And Critical Care Medicine Kochi Medical School
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ETOH Takashi
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
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