Human Papillomavirus DNA in Female Condylomata
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概要
- 論文の詳細を見る
今回我々は外陰・膣・子宮頚部の尖圭コンジローマ60検体と子宮頚部のflat condyloma4検体におけるヒトパピローマウィルス(HPV)ゲノムの存在と存在様式をHPV6型及び11型に対するDNAハイブリット法で検討した.尖圭コンジローマ60検体中55検体とflat condyloma4検体中1検体に細胞DNAには組込まれない遊離のHPV6型関連DNAがhaigh stringency条件下で証明された.このHPV6型関連DNA制限酵素PstIの切断パターンやHPV6型の11型に対するhybridizationの強さの差で型決定することを試み,35検体のうち,29検体(外陰20検体,膣3検体,子宮頚部6検体)の尖圭コンジローマ1検体のflat condylomaはHPV 6型,6検体(すべて外陰)はHPV11型であることが同定された.これらの結果はHPV 6型と11型がコンジローマと深く関連していることを示している.また各症例を検討した結果,同一患者の複数の病変や初発・再発病変で,病変の形態にかかわらずHPVの型が同一であることが証明された.
- 社団法人日本産科婦人科学会の論文
- 1985-07-01
著者
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YOSHIKAWA Hiroyuki
Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba
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Yoshikawa Hiroyuki
Division Of Cardiology Department Of Medicine Wakayama Medical College
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KAWANA Takashi
Departments of Obstetrics and Gynecology, Tokyo University Branch Hospital
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YOSHIIKE Kunito
Division of Molecular Genetics, National Institute of Infectious Diseases
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Yoshiike Kunito
Division Of Molecular Genetics National Institute Of Infectious Diseases
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Yoshiike Kunito
Department Of Enteroviruses National Institute Of Health
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Yoshikawa Hiroyuki
Department Of Obstetrics And Gynecology Faculty Of Medicine University Of Tokyo
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Yoshikawa H
Hokkaido Univ. Sapporo Jpn
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Kawana Takashi
Department Of Obstetrics And Gynecology Faculty Of Medicine University Of Tokyo
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MATSUKURA Toshihiko
Department of Enteroviruses, National Institute of Health
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YAMAMOTO Etsutaro
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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MIZUNO Masahiko
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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Yamamoto Etsutaro
Department Of Obstetrics And Gynecology Faculty Of Medicine University Of Tokyo
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Yoshikawa Hiroyuki
Department Of Applied Physics Osaka University
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Kawana Takashi
Department Of Obstetrics & Gynecology Tokyo University Branch Hospital
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Mizuno Masahiko
Department Of Obstetrics And Gynecology Faculty Of Medicine University Of Tokyo
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Matsukura T
National Inst. Infectious Diseases Tokyo Jpn
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Mizuno Masahiko
Department Of Neurosurgery And Pediatrics Kansai Medical School
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Kawana Takashi
Department Of Gynecology Faculty Of Medicine University Of Tokyo
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Yoshikawa Hiroyuki
Department Of Applied Physics And Handai Frontier Research Center Osaka University
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