Intracellular Free Calcium Concentration, Ca^<++> Channel and Calmodulin Level in Experimental Hypertension in Rats
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概要
- 論文の詳細を見る
Using fluorescent calcium indicator quin2, we studied intracellular free calcium concentration in platelets that have a number of features similar to vascular smooth muscle cells. Intracellular free calcium concentration in platelets of male SHR was significantly higher at 4, 11 and 28 weeks old compared with age-matched male WKY. However, no significant difference was observed in platelets cytosolic free calcium level of DOCA-salt hypertensive and two-kidney, one clip hypertensive rats in the chronic stage. Cardiac Ca^<++> channels were estimated by means of radioligand binding method with [^3H]-nimodipine. No significant changes were observed in the concentration and affinity of cardiac Ca^<++> channel in SHR, DOCA-salt hypertensive and two-kidney, one clip hypertensive rats. Calmodulin levels in mesenteric arteries of SHR were significantly decreased in comparison with those of WKY. However no significant differences were observed in DOCA-salt hypertensive rats in the chronic stage. These results indicate that the increase in intracellular free calcium concentration of SHR is not the secondary change caused by high blood pressure. It is impossible to detect the ratio of the three states (open, resting and inactivated) of Ca^<++> channel. Therefore, there remains a possibility of the changes in the ratio of he states of Ca^<++> channel. The observed abnormalities of Ca^<++> regulation may contribute to the pathogenesis of hypertension.
- 社団法人日本循環器学会の論文
- 1987-10-20
著者
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Yoshikawa Hiroyuki
Division Of Cardiology Department Of Medicine Wakayama Medical College
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Hano Takuzo
Division Of Cardiology Department Of Medicine Wakayama Medical College
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Baba Akira
Department Of Cardiovascular Medicine Wakayama Medical University
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Nishio Ichiro
Division Of Cardiology Department Of Medicine Wakayama Medical College
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Ishii Noriko
Division Of Cardiology Department Of Medicine Wakayama Medical University
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Nishio Ichiro
Division Of Cardiology Department Of Internal Medicine Wakayama Medical College
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Kuchii Masato
Division of Cardiology, Department of Medicine. Wakayama Medical College, Japan
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Masuyama Yoshiaki
Division of Cardiology, Department of Medicine. Wakayama Medical College, Japan
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Fukuda Kazuya
Division of Cardiology, Department of Medicine, Wakayama Medical College
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Baba Akira
Division of Cardiology, Department of Medicine, Wakayama Medical College
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Ura Masako
Division of Cardiology, Department of Medicine, Wakayama Medical College
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HAMADA MASANORI
Division of Cardiology, Department of Medicine, Wakayama Medical College
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Fukuda Kazuya
Division Of Cardiology Department Of Medicine Wakayama Medical College
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Baba A
Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University
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Masuyama Yoshiaki
Division Of Cardiology Social Insurance Kinan Hospital
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Yoshikawa H
Hokkaido Univ. Sapporo Jpn
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Hamada Masanori
Division Of Cardiology Department Of Medicine Wakayama Medical College
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Ura Masako
Division Of Cardiology Department Of Medicine Wakayama Medical College
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Kuchii Masato
The Department Of Internal Medicine Arida Municipal Hospital Arida Wakayama
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Kuchii Masato
Division Of Cardiology Department Of Medicine Wakayama Medical College
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Masuyama Yoshiaki
Division Of Cardiology Department Of Medicine Wakayama Medical College
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Fukuda K
Division Of Cardiology Department Of Medicine Wakayama Medical College
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