Neurotransmitter Release and Vascular Reactivity in Spontaneously Hypertensive Rats : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION

スポンサーリンク

概要

• 論文の詳細を見る

• This study was designed to investigate neurotransmitter release during the sympathetic nerve stimulation of perfused mesenteric arterial beds of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) at young and adult ages. The role of Ca in neurotransmitter release and vascular responsiveness was also examined by using a Ca-antagonist (verapamil). Pressor responses to electrical nerve stimulation and exogenous noradrenaline were greater in SHR than in WKY. Noradrenaline overflow by electrical nerve stimulation from mesenteric arterial beds was also significantly greater in young SHR than age-matched WKY. However, in adult SHR, the noradrenaline overflow was reduced compared with WKY. After verapamil infusion (5.0×10^<-7>M~2.5×10^<-6>M), suppression of the pressor responses and noradrenaline overflow evoked by electrical nerve stimulation was greater in SHR than in WKY at both ages. The pressor responses to exogenous noradrenaline were also inhibited by verapamil more in young SHR than in young WKY. In adult SHR, the inhibition was similar to age-matched WKY. These results suggest that noradrenaline release from sympathetic nerve endings in SHR increase at a young age and decreases in adults, and depends at least partly on Ca-influx at both ages as dose vascoconstrictor reactivity. Therefore, Ca-dependency in SHR at both pre- and post-synaptic sites of neurotransmission may contribute to the pathogenesis of hypertension.

• 社団法人日本循環器学会の論文
• 1984-11-20

著者

• Hano Takuzo

  Division Of Cardiology Department Of Medicine Wakayama Medical College

• KUSUYAMA Yoshio

  Division of Cardiology, Wakayama National Hospital

• Nishio Ichiro

  Division Of Cardiology Department Of Medicine Wakayama Medical College

• Nishio Ichiro

  Division Of Cardiology Department Of Internal Medicine Wakayama Medical College

• Tsuda Kazushi

  Division of Cardiology, Department of Medicine. Wakayama Medical College, Japan

• Kuchii Masato

  Division of Cardiology, Department of Medicine. Wakayama Medical College, Japan

• Kusuyama Yoshio

  Division Of Cardiology Department Of Medicine Wakayama Medical College

• MATSUYAMA YOSHIAKI

  Division of Cardiology, Department of Internal Medicine, Wakayama Medical College

• Kuchii Masato

  The Department Of Internal Medicine Arida Municipal Hospital Arida Wakayama

• Kuchii Masato

  Division Of Cardiology Department Of Medicine Wakayama Medical College

• Tsuda Kazushi

  Division Of Cardiology Department Of Medicine Wakayama Medical University

• Kusuyama Yoshio

  The Division Of Cardiology Wakayama National Hospital

関連論文

• Predictors and Prognosis of Stent Fracture After Sirolimus-Eluting Stent Implantation
• PJ-681 Serial Angiographic Changes of Stent Fracture Site after Sirolimus-Eluting Stent Implantation(PJ114,Coronary Revascularization, PCI (DES) 4 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-350 New Type of Ca Channel Blockade, Azelnidipine Inhibits Sympathetic Tone via P/Q Type of Ca Channel(Cardiovascular Pharmacology, Basic/Clinical 3 (H) : PE60)(Poster Session (English))
• THE ABNORMALITY OF SODIUM CONTENT AND TRANSPORT IN RED BLOOD CELLS OF ESSENTIAL HYPERTENSION : Hypertension (II) : 46th Annual Scientific Meeting, Japanese Circulation Society
• CHANGES IN RENAL β-ADRENOCEPTORS IN DOCA-SALT HYPERTENSIVE RATS : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
• Changes in Cardiac Beta-Adrenoceptor Concentrations in Spontaneously Hypertensive and Experimental Renal Hypertensive Rats : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• CHANGES IN RENAL β-ADRENOCEPTORS IN EXPERIMENTAL HYPERTENSION IN THE RAT : Kidney・Hypertension : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
• NORADRENALINE IN PLASMA AND CEREBROSPINAL FLUID DURING FUROSEMIDE ADMINISTRATION : Kidney・Hypertension : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
• THE EFFECT OF ANGIOTENSIN II ANTAGONIST, SAR^1-ILE^8-ANGIOTENSIN II, ON FUROSEMIDE-INDUCED INCREASE IN PLASMA NORADRENALINE, RENIN ACTIVITY AND ALDOSTERONE IN UNANESTHETIZED DOGS
• PLASMA NORADRENALINE LEVEL AFTER BLOCKING THE RENIN ANGIOTENSIN ALDOSTERONE SYSTEM WITH CAPTOPRIL : Hypertension : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• THE ROLE OF THE RENIN-ANGIOTENSIN SYSTEM ON THE FUROSEMIDE-INDUCED INCREASE IN PLASMA NORADRENALINE : Hypertension : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Plasma Catecholamines Determination Using High Pressure Liquid Chromatography and Their Roles in Blood Pressure Regulation and Experimental Hypertension in Rats : VIII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• LEFT VENTRICULAR FUNCTION AND CARDIAC HYPERTROPHY IN CASES OF MILD HYPERTENSION WITH MARKED ST-T CHANGES IN ELECTROCARDIOGRAM : Hypertension I : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
• RENAL CATECHOLAMINE CLERANCE IN HYPERTENSION : Hypertension I : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
• PJ-409 High frame rate acoustic quantification enables accurate evaluation of cardiac function in rats with regional wall motion abnormality(Cardiac Function, Basic/Clinical 2 (M) : PJ68)(Poster Session (Japanese))
• PJ-137 Spotlight burst : Novel technique to assess the myocardial perfusion in real-time myocardial contrast echocardiography(Echo/Doppler 6 (I) : PJ23)(Poster Session (Japanese))
• PJ-021 Measurement of Myocardial Flow Velocity in Capillaries and Arterioles in the Myocardium by Contrast Echocardiography(Echo/Doppler 2 (I) : PJ4)(Poster Session (Japanese))
• OJ-274 An Adequate Method to Estimate the Myocardial Blood Volume by Real-time Myocardial Contrast Echocardiography(Echo/Doppler 10 (I) : OJ32)(Oral Presentation (Japanese))
• OJ-271 Hypertriglyceridemia decreases coronary flow reserve and increases myocardial blood volume : Real-time myocardial contrast echocardiographic study(Echo/Doppler 10 (I) : OJ32)(Oral Presentation (Japanese))
• FRS-002 Measurement of Compartment Blood Volume in The Myocardium : Myocardial Contrast Echocardiographic Study(Ultrasound Medicine in Cardiology (I) : FRS1)(Featured Research Session (English))
• Apoptosis of Vascular Smooth Muscle Cells is Induced by Fas Ligand Derived From Endothelial Cells
• -P534- The non-dipper hypertensives, compared with the dipper one, are more susceptible to a calcium antagonist.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -0588- EXERCISE TRAINING ALTERS INTRACELLULAR CALCIUM TRANSIENTS IN ISOLATED CARDIOMYOCYTES OF RATS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• THE ABNORMALITIES IN INTRACELLUALR CALCIUM TRANSIENT OF ISOLATED LEFT VENTRICULAR MYOCYTE FROM HYPERTENSIVE HYPERTROPHIED HEART
• INCREASED NUMBER OF Ca^-INDUCED Ca^CHANNEL IN HYPERTROPHIED HEART OF EXPERIMENTAL HYPERTENSION
• -0232-ABNORMALITY OF PG PRODUCTION, ITS RECEPTORS AND INTRACELLULAR SIGNAL TRANSDUCTION SYSTEM ON THE PATHOGENESIS AND THE MAINTENANCE OF HYPERTENSION
• -0230-DETERMINATION OF PHOSPHATIDYL INOSITOL 1, 4, 5-TRISPHOSPHATE RECEPTORS IN RAT HEART AND ITS CHANGE IN SPONTANEOUSLY HYPERTENSIVE RATS
• -0225-INTRACELLULAR CA STORE IN VASCULAR SMOOTH MUSCLE CELLS OF SPONTANEOUS HYPERTENSIVE RATS
• CHANGES IN CARDIAC α_1-ADRENOCEPTOR IN SPONTANEOUSLY HYPERTENSIVE RATS : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• CONTRIBUTION OF SYMPATHETIC NERVOUS SYSTEM TO THE AMBULATORY BLOOD PRESSURE VALUES IN ESSENTIAL HYPERTENSION : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• -P125-ATTENUATED RESPONSE OF URINARY PROSTAGLANDINS TO STANDING IN ESSENTIAL HYPERTENSION : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Intracellular Free Calcium Concentration, Ca^ Channel and Calmodulin Level in Experimental Hypertension in Rats
• -1044-INHIBITION OF NOREPINEPHRINE UPTAKE BY ENDOGENOUS DIGITALIS-LIKE SUBSTANCE : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• THE EFFECTS OF COLD STRESS AND SYMPATHECTOMY ON CARDIAC AND ERYTHROCYTE β-ADRENOCEPTOR IN SPONTANEOUSLY HYPERTENSIVE RATS : Sympathetic Function : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• EFFECTS OF INDOMETHACIN ON BLOOD PRESSURE AND CARDIAC α_1-AND β-ADRENOCEPTORS : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• EFFECT OF VERAPAMIL ON CARDIAC AND RENAL α-ADRENOCEPTORS IN EXPERIMENTAL HYPERTENSVE : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• THE α_2-ADRENOCEPTOR IN HUMAN LYMPHOCYTES : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• Changes in Renalα_2-Adrenoceptor in Experimental Hypertension in Rats : The 12th Conference on the Pathogenesis of Hypertension
• CHANGES IN RENAL α_1-ADRENOCEPTOR IN EXPERIMENTAL HYPERTENSION IN THE RAT : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• 0918 A BASIC EXPERIMENT AND CLINICAL STUDY FOE THE MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY(MCE).
• RENAL DOPAMINE CONTENTS IN EXPERIMENTAL HYPERTENSION IN RATS : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• EFFECT OF Ca-ANTAGONIST ON NORADRENALINE RELEASE IN THE SYMPATHETIC NERVE ENDINGS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• THE ROLE OF ADRENAL GLAND IN PLASMA DOPAMINE CHANGES BY HEMORRHAGE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• PLATELET NORADRENALINE CONTENT AS AN INTEGRATED MEASURE OF VARIATIONS IN PLASMA NORADRENALINE : The 53th Annual Scientific Session of the Japanese Circulation Society
• Enhanced Calcium-Sensitivity of Erythrocytes in Hypertension : Calcium-induced Changes of Erythrocyte Osmotic Fragility in Essential Hypertension : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• -84-EVALUATION OF PLATELET NORADRENALINE : IN RELATION TO THE SYMPATHETIC NERVE ACTIVITY
• ALTERATIONS OF PRESYNAPTIC α_2-MEDIATED INHIBITION OF NOREPINEPHRINE RELEASE IN PERFUSED MESENTERIC PREPARATIONS OF SPONTANEOUSLY HYPERTENSIVE RATS & DOCA-SALT HYPERTENSION : Hypertension (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIE
• Neurotransmitter Release and Vascular Reactivity in Spontaneously Hypertensive Rats : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• NEUROTRANSMITTER RELEASE, VASCULAR RESPONSIVENESS AND THEIR Ca-DEPENDENCY IN PERFUSED MESENTERIC PREPARATION OF DOCA-SALT HYPERTENSIVE RATS : Hypertension(II) : II : 48 Annual Scientific Meeting, Japanese Circulation Society
• LEFT VENTRICULAR FUNCTION AND CARDIAC HYPERTROPHY IN CASES OF MILD HYPERTENSION WITH MARKED ST-T CHANGES IN ELECTROCARDIOGRAM : Nuclear Cardiology : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -138-PLASMA CATECHOLAMINES IN EXPERIMENTAL HYPERTENSION IN THE RAT : Hypertension,Catecholamine : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -83-EPINEPHRINE RELEASE FROM THE PERFUSED ADRENAL MEDULLA OF SPONTANEOUSLY HYPERTENSIVE RATS
• Estrogen Reduces Angiotensin II-Induced Acceleration of Senescence in Endothelial Progenitor Cells
• -0650- EFFECTS OF ISOPROTERENOL AND PHENYLEPHRINE ON QUINIDINE INDUCED QT PROLONGATIONS AND EARLY AFTER DEPOLARIZATION IN DOGS.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -0204- THE CORONARY ANGIOGRAPHIC CHARACTERISTICS AND PROGNOSIS IN VASOSPASTIC ANGINA PECTORIS(VAP)(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -0125- Assessment of myocardial fatty acid metabolism using ^I-BMIPP myocardial scintigraphy in patients with essential hypertension(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• P463 EFFECT OF WALKING ON AUTONOMIC ACTIVITY IN MILD HYPERTENSIVE PATIENTS
• -0558-NERVE GROWTH FACTOR INCREASES IN SPONTANEOUSLY HYPERTENSIVE RATS
• Effects of Locally Administration of Argatroban Using a Hydrogel-Coated Balloon Catheter on Intimal Thickening Induced by Balloon Injury
• P076 VASCULAR MECHANISMS IN NITRIC OXIDE INHIBITION
• THE EFFECTS OF CATECHOLAMINES ON DNA AND PROTEIN SYNTHESIS IN RAT'S CULTURED ARTERIAL SMOOTH MUSCLE CELLS : Sympathetic Function : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• A Premenopausal Woman Presenting With Acute Myocardial Infarction of Three Different Coronary Vessels Within 1 Year : Role of Lipoprotein(a)
• Effect of Estrogen on Differentiation and Senescence in Endothelial Progenitor Cells Derived from Bone Marrow in Spontaneously Hypertensive Rats
• Angiotensin II Potentiates Vascular Endothelial Growth Factor-Induced Proliferation and Network Formation of Endothelial Progenitor Cells
• Oxidized Low Density Lipoprotein Potentiation of Fas-Induced Apoptosis Through Lectin-Like Oxidized-Low Density Lipoprotein Receptor-1 in Human Umbilical Vascular Endothelial Cells
• Acute Effect of Endothelin AB Antagonist on Sympathetic Outflow in Conscious Rats With Heart Failure
• Dynamic Outflow Obstruction due to Transient Extensive Left Ventricular Wall Motion Abnormalities Caused by Acute Myocarditis in a Patient With Hypertrophic Cardiomyopathy : Reduction in Ventricular Afterload by Disopyramide
• Pheochromocytoma-Related Myocardial Damage Following Delivery
• P662 ESTROGEN SUPPRESSES VASCULAR RESPONSIVENESS THROUGH ENDOTHELIAL FACTORS IN RAT MESENTERIC ARTERY
• PRESSOR RESPONSE AND NOREPINEPHRINE OVERFLOW AFTER REMOVAL OF THE ENDOTHELIUM IN THE MESENTERIC ARTERY OF SPONTANEOUSLY HYPERTENSIVE RATS : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• EFFECTS OF TAURINE ON NOREPINEPHRINE OVERFLOW FROM THE SYMPATHETIC NERVE TERMINALS IN MESENTERIC ARTERIAL PREPARATION : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• Plasma Noradrenaline and its Deaminated Metabolites in Essential Hypertension and Pheochromacytoma : THE 14th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• RELEASE OF PROSTAGLANDIN E_2 FOLLOWING NERVE STIMULATION IN THE PERFUSED RAT MESENTERIC ARTERY-INTESTINAL LOOP PREPARATION : Hypertension (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Dopamine Contents in Spontaneously Hypertensive and DOCA-salt Hypertensive Rats
• A Case of Orthostatic and Postexertional Hypotension with Ischemic Electrocardiographic Changes.
• Augmented Cyclic AMP-dependent Phosphorylation in Spontaneously Hypertensive Rats
• Abnormal Regulation of Angiotensin II Receptor Type I Gene Expression in The Adrenal Gland of Spontaneously Hypertensive Rats
• Effects of Nicardipine on Platelets Cytosolic Free Calcium Concentration of Spontaneously Hypertensive Rats
• LOCALIZATION OF NERVE GROWTH FACTOR MESSENGER RNA IN SPONTANEOUSLY HYPERTENSIVE RATS
• Production of Nerve Growth Factor in Cell Culture of Vascular Smooth Muscle Cells and in Tissue Culture of Mesenteric Artery and Aorta Segments derived from Spontaneously Hypertensive rats and Wistar-Kyoto rats
• The effect of antihypertensive agents on cell proliferation in cultured vascular smooth muscle cells from different strains of genetically hypertensive rats
• Effect of extracellualr calcium removal on intracellular free calcium concentration in cultured vascular smooth muscle cells from two different strains of genetically hypertensive rats
• Effects of dopamine on urinary sodium excretion in spontaneously hypertensive rats
• An Important Role of Alpha 1A Adrenoceptor in the Increased Vascular Contraction in Spontaneously Hypertensive Rats
• Impaired an Arterial Baroreflex Function in Prehypertensive and Hypertensive Spontaneously Hypertensive Rats
• Effect of Verapamil on Cardiac and Renal α-Adrenoceptors in Spontaneously Hypertensive Rats
• Changes in Cardiac Ca++ Channel in Spontaneously Hypertensive Rats
• Increased Concentration of Renal α1- and α2-Adrenoceptors in Spontaneously Hypertensive Rats
• cAMP Response to PGE2 in Renal Medulla of Young Spontaneously Hypertensive Rats and the Early DOCA-salt Hypertension
• Effects of calcium supplementation on blood pressure in spontaneously hypertensive rats
• Production of Nerve Growth Factor in Cultured Vascular Smooth Muscle Cells from Genetically Hypertensive rats
• Effects of Calcium-Calmodulin System on Renin Release from Isolated Superfused Glomeruli in Spontaneously Hypertensive Rats
• Effects of Dopamine on Norepinephrine Overflow in Perfused Kidney of SHR
• 6-keto-PGF1α Outflows in the Perfused Mesenteric Artery-Intestinal Loop Preparation from Spontaneously Hypertensive Rats
• Neurotransmitter Release and Vascular Reactivity in Young and Adult Spontaneously Hypertensive Rats
• Effects of Prostaglandins on Norepinephrine Release and Vascular Responsiveness in mesenteric vasculature of Spontaneously Hypertensive Rats
• Reduction of inhibitory effects of adrenergic tranmission by NGF in the mesenteric vasculature in SHR
• Changes in α- and β-Adrenoceptors in Spontaneously Hypertensive Rats
• The Effect of Inhibition of the Sympathetic Nervous System on Aortic Acid Mucopolysaccharides in Spontaneously Hypertensive Rats
• Intracellular Free Calcium Concentration in Platelets of Spontaneously Hypertensive and DOCA-salt Hypertensive Rats

もっと見る 閉じる

スポンサーリンク