Effects of Locally Administration of Argatroban Using a Hydrogel-Coated Balloon Catheter on Intimal Thickening Induced by Balloon Injury

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The purpose of this study was to evaluate the inhibitory effects of locally delivered argatroban, a competitive inhibitor of thrombin-induced platelet activation, on intimal proliferation after balloon injury. A hydrogelcoated balloon catheter was immersed 3 times in an argatroban/saline solution (1, 0.1, or 0.01 mg/ml) for 60 s and inflated at 6 atm pressure for 1 rain in the rabbit common carotid artery. Immersion in a saline solution without drug followed by the same procedure served as a control. Accumulation of argatroban in the vascular wall was confirmed by chemical determination using high-performance liquid chromatography (HPLC). The concentration of argatroban in the vessel wall immediately after deflation after balloon immersion in solutions of 1 and 0.1 mg/ml was 14.8±10.9 and 5.5±4.6 nmol/g wet weight of artery, respectively. Argatroban was not detected in arteries treated with a balloon that had been immersed in the 0.01 mg/ml argatroban/saline solution. Intima-media area ratios 20 days after balloon injury in the groups treated with 1 mg/ml (n=8) and 0.1 mg/ml (n=6) agratoban were significantly smaller than that in the groups treated with 0.01 mg/ml (n=7) argatroban or saline (n=8) (0.35±0.11, 0.50±0.17, 1.24±0.39, and 1.35±0.43, respectively; p<0.001). These data suggest that locally administered argatroban dose-dependently inhibits intimal thickening in a rabbit model of carotid artery injury.
社団法人日本循環器学会の論文
1997-02-20

Effects of Locally Administration of Argatroban Using a Hydrogel-Coated Balloon Catheter on Intimal Thickening Induced by Balloon Injury

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