Central actions of circulating angiotensin II on the sympathetic nervous system and blood pressure control.

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概要

• 論文の詳細を見る

• The effects of intravertebral artery infusions of [Sar1, Ile8] and [Sar1, Thr8] angiotensin II on the central nervous system were studied in furosemide-treated dogs anesthetized with α-chloralose. Acute administration of furosemide led to a significant increase in plasma renin activity, plasma noradrenaline levels and heart rate, and also to a slight rise of blood pressure. In the furosemidetreated dogs, intravertebral artery infusion of either angiotensin II antagonist (250ng/Kg/min, for 30min) suppressed the furosemideinduced increases in plasma noradrenaline, heart rate and arterial blood pressure. The effects of [Sar1, Thr8] angiotensin II on the last two parameters were more pronounced than those of [Sar1, Ile8] angiotensin II. Intravenous infusion of the same dose of each antagonist had little influence on the furosemide-induced increases in arterial blood pressure, heart rate and plasma noradrenaline levels. These results suggest that the central actions of angiotensin II contribute to the regulation of blood pressure through the sympathetic nervous system.

• International Heart Journal刊行会の論文

著者

• Arita Mikio

  Division Of Cardiology Department Of Medicine Wakayama Medical College

• Ueno Yuji

  Division Of Cardiology Department Of Medicine Wakayama Medical College

• KHOSLA Mahesh

  Division of Research, Cleveland Clinic

• Suruda Hidetoshi

  Division Of Cardiology Department Of Medicine Wakayama Medical College

• Masuyama Yoshiaki

  Division Of Cardiology Department Of Medicine Wakayama Medical College

• Mohara Osamu

  Division Of Cardiology Department Of Medicine Wakayama Medical College

• Arita Mikio

  Division of Cardiology, Department of Medicine, Wakayama Medical College

• UENO Yuji

  Division of Cardiology, Department of Medicine, Wakayama Medical College

• BUMPUS F.

  Division of Cardiology, the Cleveland Clinic Foundation

• KHOSLA Mahesh

  Division of Cardiology, the Cleveland Clinic Foundation

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