Comparative Biochemistry of Renins and Angiotensins in the Vertebrates

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概要

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• Comparative biochemistry of renins and angiotensins was discussed. Renin extracted from hog kidney was different from that from mouse submaxillary glands in immunoreactivity and carbohydrate content. Rat kidney renin was also different from hog kidney renin in the amino acid composition. The presence of big and big-big renins was pointed out immunochemically. These big renins were considered to be precursors of kidney renin.Angiotensins in mammalian and nonmammalian species produced by renal or extrarenal renin have been differentiated by some biochemical and pharmacological criteria. Some of these angiotensins were analyzed sequentially. The replacements of amino acid residues at positions 1, 5, and/or 9 of angiotensin I have been demonstrated in nonmammalian species.Specific pressor activities have been determined using synthetic angiotensins by a 4 point assay in rat. Specific pressor activities of various angiotensins were obtained from the dose-blood pressure-response curves using a single angiotensin sample per assay rat.

• International Heart Journal刊行会の論文

著者

• NAKAJIMA TERUMI

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• SAKAKIBARA SHUMPEI

  Peptide Institute Inc., Protein Research Foundation

• KHOSLA Mahesh

  Division of Research, Cleveland Clinic

• Sakakibara Shumpei

  Peptide Institute Inc. Protein Research Foundation

• Nakajima Terumi

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• NAKAJIMA Terumi

  Institute of Pharmaceutical Sciences, Hiroshima University, Shool of Medicine

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