INHIBITION OF ADRENERGIC TRANSMISSION BY METHIONINE- AND LEUCINE-ENKEPHALINS IS IMPAIRED IN THE MESENTERIC VASCULATURES OF SPONTANEOUSLY HYPERTENSIVE RATS

スポンサーリンク

概要

• 論文の詳細を見る

• The present study was carried out to investigate the effects of enkephalins (methionine-enkephalin: Met-Enk, leucine-enkephalin: Leu-Enk) on the adrenergic neurotransmission in hypertension. Perfused mesenteric vasculatures were prepared in spontaneously hypertensive rats (SHR, Okamoto and Aoki strain, 7-10 weeks old) and age-matched Wistar Kyoto rats (WKY), and the effects of these peptides on vascular responsiveness as well as norepinephrine release from the sympathetic nerve endings were examined. Pressor responses to eleectrical nerve stimulation were inhibited in a does-dependent manner by Met-Enk and Leu-Enk, and the inhibition was antagonized by naloxone. Norepinephrine release during electrical nerve stimulation was also suppressed by these peptides. In SHR, stimulation-evoked pressor responses and norepinephrine release were significantly enhanced compared to those in WKY, while the suppressive magnitudes of the responses by Met-Enk and Leu-Enk were smaller in SHR than in WKY. These results demonstrate that Met-Enk and Leu-Enk affected presynaptic sites of blood vessels and caused a decrease in electrically-stimulated norepinephrine release from the sympathetic nerve endings. The lower reduction in norepinephrine release and vascular responsiveness by Met-Enk and Leu-Enk in SHR suggests an insufficient regulation of the vascular adrenergic neurotransmission by the opioid peptides in this model of hypertension.

• 社団法人日本循環器学会の論文
• 1989-03-20

著者

• Masuyama Yoshiaki

  Division of Cardiology, Department of Medicine. Wakayama Medical College, Japan

• Tsuda Kazushi

  Neurochemistry Research Unit New York University Medical Center School Of Medicine

• Masuyama Yoshiaki

  Division Of Cardiology Department Of Medicine Wakayama Medical College

関連論文

• THE ABNORMALITY OF SODIUM CONTENT AND TRANSPORT IN RED BLOOD CELLS OF ESSENTIAL HYPERTENSION : Hypertension (II) : 46th Annual Scientific Meeting, Japanese Circulation Society
• CHANGES IN RENAL β-ADRENOCEPTORS IN DOCA-SALT HYPERTENSIVE RATS : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
• Changes in Cardiac Beta-Adrenoceptor Concentrations in Spontaneously Hypertensive and Experimental Renal Hypertensive Rats : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• CHANGES IN RENAL β-ADRENOCEPTORS IN EXPERIMENTAL HYPERTENSION IN THE RAT : Kidney・Hypertension : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
• NORADRENALINE IN PLASMA AND CEREBROSPINAL FLUID DURING FUROSEMIDE ADMINISTRATION : Kidney・Hypertension : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
• THE EFFECT OF ANGIOTENSIN II ANTAGONIST, SAR^1-ILE^8-ANGIOTENSIN II, ON FUROSEMIDE-INDUCED INCREASE IN PLASMA NORADRENALINE, RENIN ACTIVITY AND ALDOSTERONE IN UNANESTHETIZED DOGS
• PLASMA NORADRENALINE LEVEL AFTER BLOCKING THE RENIN ANGIOTENSIN ALDOSTERONE SYSTEM WITH CAPTOPRIL : Hypertension : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• THE ROLE OF THE RENIN-ANGIOTENSIN SYSTEM ON THE FUROSEMIDE-INDUCED INCREASE IN PLASMA NORADRENALINE : Hypertension : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Plasma Catecholamines Determination Using High Pressure Liquid Chromatography and Their Roles in Blood Pressure Regulation and Experimental Hypertension in Rats : VIII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• LEFT VENTRICULAR FUNCTION AND CARDIAC HYPERTROPHY IN CASES OF MILD HYPERTENSION WITH MARKED ST-T CHANGES IN ELECTROCARDIOGRAM : Hypertension I : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
• RENAL CATECHOLAMINE CLERANCE IN HYPERTENSION : Hypertension I : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
• -0232-ABNORMALITY OF PG PRODUCTION, ITS RECEPTORS AND INTRACELLULAR SIGNAL TRANSDUCTION SYSTEM ON THE PATHOGENESIS AND THE MAINTENANCE OF HYPERTENSION
• -0230-DETERMINATION OF PHOSPHATIDYL INOSITOL 1, 4, 5-TRISPHOSPHATE RECEPTORS IN RAT HEART AND ITS CHANGE IN SPONTANEOUSLY HYPERTENSIVE RATS
• -0225-INTRACELLULAR CA STORE IN VASCULAR SMOOTH MUSCLE CELLS OF SPONTANEOUS HYPERTENSIVE RATS
• CHANGES IN CARDIAC α_1-ADRENOCEPTOR IN SPONTANEOUSLY HYPERTENSIVE RATS : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• CONTRIBUTION OF SYMPATHETIC NERVOUS SYSTEM TO THE AMBULATORY BLOOD PRESSURE VALUES IN ESSENTIAL HYPERTENSION : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• -P125-ATTENUATED RESPONSE OF URINARY PROSTAGLANDINS TO STANDING IN ESSENTIAL HYPERTENSION : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Intracellular Free Calcium Concentration, Ca^ Channel and Calmodulin Level in Experimental Hypertension in Rats
• -1044-INHIBITION OF NOREPINEPHRINE UPTAKE BY ENDOGENOUS DIGITALIS-LIKE SUBSTANCE : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• THE EFFECTS OF COLD STRESS AND SYMPATHECTOMY ON CARDIAC AND ERYTHROCYTE β-ADRENOCEPTOR IN SPONTANEOUSLY HYPERTENSIVE RATS : Sympathetic Function : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -88-CARDIAC [^3H]-NIMODIPINE BINDING IN EXPERIMENTAL HYPERTENSION IN RATS
• EFFECT OF Ca-ANTAGONISTS ON CARDIAC AND RENAL α-ADRENOCEPTORS IN EXPERIMENTAL HYPERTENSIVE RATS : Hypertension (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• CHANGES IN LYMPHOCYTE AND PLATELET β-ADRENOCEPTORS IN EXPERIMENTAL HYPERTENSION IN RATS : Hypertension (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• EFFECTS OF INDOMETHACIN ON BLOOD PRESSURE AND CARDIAC α_1-AND β-ADRENOCEPTORS : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• EFFECT OF VERAPAMIL ON CARDIAC AND RENAL α-ADRENOCEPTORS IN EXPERIMENTAL HYPERTENSVE : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• THE α_2-ADRENOCEPTOR IN HUMAN LYMPHOCYTES : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• Changes in Renalα_2-Adrenoceptor in Experimental Hypertension in Rats : The 12th Conference on the Pathogenesis of Hypertension
• CHANGES IN RENAL α_1-ADRENOCEPTOR IN EXPERIMENTAL HYPERTENSION IN THE RAT : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• RENAL DOPAMINE CONTENTS IN EXPERIMENTAL HYPERTENSION IN RATS : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• EFFECT OF Ca-ANTAGONIST ON NORADRENALINE RELEASE IN THE SYMPATHETIC NERVE ENDINGS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• THE ROLE OF ADRENAL GLAND IN PLASMA DOPAMINE CHANGES BY HEMORRHAGE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• STUDIES OF REHABILITATION FOR ACUTE MYOCARDIAL INFARCTION WITH MULTISTAGE TREADMILL EXERCISE TEST : Exercise Test : 46th Annual Scientific Meeting, Japanese Circulation Society
• PLATELET NORADRENALINE CONTENT AS AN INTEGRATED MEASURE OF VARIATIONS IN PLASMA NORADRENALINE : The 53th Annual Scientific Session of the Japanese Circulation Society
• Enhanced Calcium-Sensitivity of Erythrocytes in Hypertension : Calcium-induced Changes of Erythrocyte Osmotic Fragility in Essential Hypertension : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• -84-EVALUATION OF PLATELET NORADRENALINE : IN RELATION TO THE SYMPATHETIC NERVE ACTIVITY
• THE ROLE OF THE RENIN ANGIOTENSIN SYSTEM IN THE REGULATION OF BLOOD PRESSURE OF SODIUM LOADED STATES : Hypertension (II) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• ALTERATIONS OF PRESYNAPTIC α_2-MEDIATED INHIBITION OF NOREPINEPHRINE RELEASE IN PERFUSED MESENTERIC PREPARATIONS OF SPONTANEOUSLY HYPERTENSIVE RATS & DOCA-SALT HYPERTENSION : Hypertension (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIE
• NEUROTRANSMITTER RELEASE, VASCULAR RESPONSIVENESS AND THEIR Ca-DEPENDENCY IN PERFUSED MESENTERIC PREPARATION OF DOCA-SALT HYPERTENSIVE RATS : Hypertension(II) : II : 48 Annual Scientific Meeting, Japanese Circulation Society
• LEFT VENTRICULAR FUNCTION AND CARDIAC HYPERTROPHY IN CASES OF MILD HYPERTENSION WITH MARKED ST-T CHANGES IN ELECTROCARDIOGRAM : Nuclear Cardiology : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -138-PLASMA CATECHOLAMINES IN EXPERIMENTAL HYPERTENSION IN THE RAT : Hypertension,Catecholamine : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• EFFECTS OF FUROSEMIDE ADMINISTRATION AND ACUTE RENAL ARTERY CONSTRICTION ON CEREBROSPINAL FLUID AND PLASMA NOREPINEPHRINE : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
• The Cause of Death, Risk Factors and Long-Term Prognosis of Acute Myocardial infarction : PANEL DISCUSSION ON MORTALITY AND MORBIDIRY TRENDS IN ACUTE MYOCARDIAL INFARCTION IN JAPAN AND EMERGENCY CARE FOR IT : 50th Annual Scientific Session of the Japanese
• -0558-NERVE GROWTH FACTOR INCREASES IN SPONTANEOUSLY HYPERTENSIVE RATS
• THE EFFECTS OF CATECHOLAMINES ON DNA AND PROTEIN SYNTHESIS IN RAT'S CULTURED ARTERIAL SMOOTH MUSCLE CELLS : Sympathetic Function : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -1080-EVALUATION OF FLOW PATTERNS OF THE CORONARY ARTERIES AND VEINS USING CINE-MRI : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Regression of Left Ventricular Hypertrophy in Hypertensive Patients : Responses to Exercise by Antihypertensive Treatment : 53th Annual Scientific Session of the Japanese Circulation Society
• Membrane Fluidity of Erythrocytes and its Relevance to Renin Profile in Essential Hypertension : THE 17th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• EVIDENCE IN VOLUME-DEPENDENT HYPERTENSION FOR AN AUGMENTING FACTOR FOR NOREPINEPHRINE OVERFLOW FROM SYMPATHETIC NERVE ENDINGS
• -481- EFFECTS OF Ca-ANTAGONIST ON SYMPATHETIC NERVE ACTIVITY AND VASCULAR RESPONSIVENESS IN REDUCED RENAL MASS-SALT HYPERTENSIVE RATS
• INHIBITORY ACTION ON ALPHA-HUMAN ATRIAL NATRIURETIC POLYPEPTIDE ON VASCULAR ADRENERGIC NEUROTRANSMISSION IS ATTENUATED IN SPONTANEOUSLY HYPERTENSIVE RATS
• THE ROLE OF THE BRAIN RENING-ANGIOTENSIN SYSTEM IN THE NEUROENDOCREIN RESPONSES TO INCREASED CEREBROSPINAL FLUID SODIUM LEVELS : Hypertension(II) : II : 48 Annual Scientific Meeting, Japanese Circulation Society
• CHANGES IN PLASMA NOREPINEPHRINE AFTER INTRAVERTEBRAL ARTERY INFUSION OF SARALASIN IN SODIUM DEPLETED DOGS
• EFFECTS OF CENTRAL AND PERIPHERAL ANGIOTENSIN BLOCKADE ON BLOOD PRESSURE AND PLASMA NOREPINEPHRINE LEVEL IN HYPERTENSIVE RATS : Kidney・Hypertension : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
• PRESSOR RESPONSE AND NOREPINEPHRINE OVERFLOW AFTER REMOVAL OF THE ENDOTHELIUM IN THE MESENTERIC ARTERY OF SPONTANEOUSLY HYPERTENSIVE RATS : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• EFFECTS OF TAURINE ON NOREPINEPHRINE OVERFLOW FROM THE SYMPATHETIC NERVE TERMINALS IN MESENTERIC ARTERIAL PREPARATION : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• EFFECTS OF CALCIUM-ANTAGONISTS ON DOPAMINE RELEASE IN THE CENTRAL NERVOUS SYSTEM : Possible Interactions with D_2-Autoreceptors and Guanosine Triphosphate-Binding Proteins
• 0351 RELEASE OF ACETYLCHOLINE AND ITS DOPAMINERGIC CONTROL IN THE CENTRAL NERVOUS SYSTEM OF SPONTANEOUSLY HYPERTENSIVE RATS
• EFFECTS OF NICARDIPINE ON THE RELEASE OF ACETYLCHOLINE IN THE RAT CENTRAL NERVOUS SYSTEM
• -0509-THE ROLE OF CALCITONIN GENE RELATED PEPTIDE IN THE REGULATION OF NOREPINEPHRINE RELEASE IN HYPERTENSION
• Plasma Noradrenaline and its Deaminated Metabolites in Essential Hypertension and Pheochromacytoma : THE 14th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• EFFECTS OF OUABAIN ON ADRENERGIC NEUROTRANSMISSION IN SPONTANEOUSLY HYPERTENSIVE RATS
• THE ROLE OF EPINEPHRINE AS A NEUROMODULATOR IN SPONTANEOUSLY HYPERTENSIVE RATS
• INHIBITION OF ADRENERGIC TRANSMISSION BY METHIONINE- AND LEUCINE-ENKEPHALINS IS IMPAIRED IN THE MESENTERIC VASCULATURES OF SPONTANEOUSLY HYPERTENSIVE RATS
• RELEASE OF PROSTAGLANDIN E_2 FOLLOWING NERVE STIMULATION IN THE PERFUSED RAT MESENTERIC ARTERY-INTESTINAL LOOP PREPARATION : Hypertension (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -137-THE ROLE OF CIRCULATING CATECHOLAMINES IN THE PATHOGENESIS OF ESSENTIAL HYPERTENSION : Hypertension,Catecholamine : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -483- EFFECTS OF SUBSTANCE P ON NEUROTRANSMITTER RELEASE AND VASCULAR RESPONSIVENESS IN SPONTANEOUSLY HYPERTENSIVE RATS
• -82-EFFECTS OF OUABAIN ON ADRENERGIC NEURO-TRANSMISSION IN HYPERTENSION
• EFFECTS OF CALMODULIN ANTAGONISTS ON VASCULAR RESPONSIVENESS AND NOREPINEPHRINE OVERFLOW FROM THE SYMPATHETIC NERVE ENDINGS IN MESENTERIC VASCULATURES OF DOCA-SALT HYPERTENSION : Hypertension (II) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUA
• Contributions of Central Sympathetic Neural Activity to Furosemide-Induced Increases in Plasma Renin Activity and Noradrenaline
• Effects of Various Stimuli on Plasma Dopamine β-Hydroxylase Activity in Essential Hypertension with Respect to Aging and Hypertension Severity Index
• The Evaluation of Plasma Dopamine β-Hydroxylase Activity in Essential and Secondary Hypertension
• Dopamine Contents in Spontaneously Hypertensive and DOCA-salt Hypertensive Rats
• Neurotransmitter release and vascular responsiveness in mesenteric vasculatures from two-kidney, one-clip goldblatt hypertensive rats.
• THE ROLE OF NEUROPEPTIDE Y IN THE REGULATION OF NORADRENERGIC TRANSMISSION IN HYPOTHALAMUS OF SPONTANEOUSLY HYPERTENSIVE RATS
• Effects of Nicardipine on Platelets Cytosolic Free Calcium Concentration of Spontaneously Hypertensive Rats
• Effects of dopamine on urinary sodium excretion in spontaneously hypertensive rats
• Effect of Verapamil on Cardiac and Renal α-Adrenoceptors in Spontaneously Hypertensive Rats
• Inhibition of norepinephrine release by presynaptic alpha2-adrenoceptors in mesenteric vasculature preparations from chronic DOCA-salt hypertensive rats.
• Changes in Cardiac Ca++ Channel in Spontaneously Hypertensive Rats
• Effects of β-Endorphin on Norepinephrine Release in Medulla Oblongata of Normotensive and Spontaneously Hypertensive Rats
• Affinity of β-Adrenoceptor for agonist in Lymphocytes from Spontaneously Hypertensive Rats
• Increased Concentration of Renal α1- and α2-Adrenoceptors in Spontaneously Hypertensive Rats
• cAMP Response to PGE2 in Renal Medulla of Young Spontaneously Hypertensive Rats and the Early DOCA-salt Hypertension
• Effects of calcium supplementation on blood pressure in spontaneously hypertensive rats
• Central actions of circulating angiotensin II on the sympathetic nervous system and blood pressure control.
• The Role of Epinephrine in the Adrenergic Transmission in Hypertension
• Effects of Calcium-Calmodulin System on Renin Release from Isolated Superfused Glomeruli in Spontaneously Hypertensive Rats
• Effects of Dopamine on Norepinephrine Overflow in Perfused Kidney of SHR
• 6-keto-PGF1α Outflows in the Perfused Mesenteric Artery-Intestinal Loop Preparation from Spontaneously Hypertensive Rats
• The role of dopamine in the regulation of neurotransmitter release in spontaneously hypertensive rats.
• Alterations in Catecholamine Release in the Central Nervous System of Spontaneously Hypertensive Rats.
• Neurotransmitter Release and Vascular Reactivity in Young and Adult Spontaneously Hypertensive Rats
• ENHANCED SENSITIVITY TO CALCIUM OF ERYTHROCYTES IN SPONTANEOUSLY HYPERTENSIVE RATS
• Effects of Prostaglandins on Norepinephrine Release and Vascular Responsiveness in mesenteric vasculature of Spontaneously Hypertensive Rats
• The Changes of Plasma Noradrenaline in SHR and Experimental Hypertensive Rats
• Chronic Nephrotoxic Nephritis in Spontaneously Hypertensive Rats
• Nephrotoxic serum nephritis in DOCA-salt hypertension and SHR
• A case of Sjoegren's syndrome with valvular diseases.
• Increased Concentration of Renal Prostaglandin E2 Receptor in Spontaneously Hypertensive Rats
• Changes in α- and β-Adrenoceptors in Spontaneously Hypertensive Rats

もっと見る 閉じる

スポンサーリンク