The role of dopamine in the regulation of neurotransmitter release in spontaneously hypertensive rats.

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概要

• 論文の詳細を見る

• The purpose of the present study was to analyze the influence of dopamine on norepinephrine release in resistance vessels in spontaneously hypertensive rats (SHR). Perfused mesenteric vasculature preparations from spontaneously hypertensive rats (7-10 weeks old) and age-matched normotensive Wistar Kyoto rats (WKY) were used to compare the effects of dopamine on both pressor responses and norepinephrine release. Both responses to electrical nerve stimulation were significantly greater in SHR than in WKY rats. Dopamine reduced these responses in a dosedependent manner in WKY. However, this suppression of responses to electrical stimulation was attenuated in SHR. These results suggest that the enhanced adrenergic transmission in SHR may partly reflect impaired dopamine-mediated inhibition of nerve terminals, which would contribute to the pathogenesis of hypertension.

• International Heart Journal刊行会の論文

著者

• Tsuda Kazushi

  Division Of Cardiology Department Of Medicine Wakayama Medical University

• TSUDA SEIKO

  Division of Cardiology, Department of Medicine, Wakayama Medical College

• Masuyama Yoshiaki

  Division Of Cardiology Department Of Medicine Wakayama Medical College

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