Alterations in Catecholamine Release in the Central Nervous System of Spontaneously Hypertensive Rats.
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概要
- 論文の詳細を見る
The aim of the present study was to investigate alterations in catecholamine release in the central nervous system of spontaneously hypertensive rats. Slices of hypothalamus, medulla oblongata and striatum were prepared from spontaneously hypertensive rats (SHR: 9-10 weeks old) and age-matched Wistar Kyoto rats (WKY). The slices were incubated with (3H)norepinephrine (NE) or (3H)dopamine (DA), superfused with Krebs-solution in vitro, and the release of the catecholamines was compared between the two strains. The basal release of hypothalamic (3H)NE did not differ between SHR and WKY slices. However, stimulation (1 Hz)-evoked (3H)NE release was significantly greater in SHR than in WKY (percent fractional release of total tissue NE: WKY 0.494±0.019%, n=6, SHR 0.730±0.053%, n=6, p<0.05). The stimulation-evoked (3H)NE release from the medulla oblongata did not differ significantly between SHR and WKY slices.Finally stimulation-evoked release of striatal (3H)DA was significantly depressed in SHR (percent fractional release of total tissue DA: WKY 2.048±0.024%, n=6, SHR 1.460±0.068%, n=6, p<0.05).These results indicate that the release of hypothalamic NE and striatal DA are altered in SHR. It is suggested that enhanced hypothalamic noradrenergic activity and reduced striatal dopaminergic activity can increase sympathetic outflow to the periphery, which may play a role in the pathogenesis of this form of hypertension.
- International Heart Journal刊行会の論文
著者
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Tsuda Kazushi
Division Of Cardiology Department Of Medicine Wakayama Medical University
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Masuyama Yoshiaki
Division Of Cardiology Department Of Medicine Wakayama Medical College
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Goldstein Menek
Neurochemistry Reseach Laboratories, New York University Medical Center
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TSUDA Seiko
Third Department of Internal Medicine, Wakayama Medical College
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