Changes in Cardiac Beta-Adrenoceptor Concentrations in Spontaneously Hypertensive and Experimental Renal Hypertensive Rats : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION

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Cardiac β-adrenoceptors were studied in membrane fractions from spontaneously hypertensive rats (SHR) and rats with two-kidney, one clip hypertension (2K, 1C HT), using radioligand binding method. β-Adrenoceptor concentration measured by [^3H]-dihydroalprenolol (DHA) binding was significantly lower in cardiac membranes from two months old SHR than those from Wistar-Kyoto rats (WKY) (38.2 ± 2.6 vs 45.1 ± 1.8 fmol/mg protein, means ± SEM, p<0.05). Cardiac membranes from 2K, 1C HT rats had also a lower concentration of β-adrenoceptors than those from the sham-operated control rats at a week after operation (30.9 ± 2.2 vs 47.8 ± 1.6 fmol/mg protein, p<0.01). But receptor affinity remained unchanged. These reduced concentrations of β-adrenoceptors were restored to control levels at 12 months old in SHR and at 6 weeks after operation in 2K, 1C HT rats, although age-dependent decrease in β-adrenoceptor was observed. The decrease in β-adrenoceptor was associated with increase in plasma noradrenaline levels during the earlier stages of hypertension. But there is no correlation between β-adrenoceptor concentrations and plasma noradrenaline levels in the chronic stages of hypertension. No significant difference was found in activities of 5'-nucleotidase, which is a marker enzyme of cell membrane, in membrane fractions between the hypertensive hearts and the controls, suggesting that the cardiac hypertrophy is not a determinant factor for change in β-adrenoceptor. The observed decrease in β-adrenoceptor concentration may reflect an increase in sympathetic nerve avtivity during development of hypertension. In the chronic stages of hypertension, additional factors may be involved in the restoration of β-adrenoceptors.
社団法人日本循環器学会の論文
1981-09-20

Changes in Cardiac Beta-Adrenoceptor Concentrations in Spontaneously Hypertensive and Experimental Renal Hypertensive Rats : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION

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