EFFECTS OF NICARDIPINE ON THE RELEASE OF ACETYLCHOLINE IN THE RAT CENTRAL NERVOUS SYSTEM

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概要

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• Recent studies have indicated that specific dihydropyridine-sensitive Ca^<2+> channel binding sites are present in the brain, and that they play a crucial role in synaptic function. The present study was performed to determine the effects of nicardipine, a dihydropyridine-sensitive Ca^<2+> channel blocker, on the release of acetylcholine in the rat central nervous system. Striatal slices of rats which had been prelabelled with [^3H]acetylcholine were superfused with Krebs-Ringer solution. The slices were stimulated with either electrical pulses (1 Hz) or an excitatory amino acid, L-glutamate, and the effects of nicardipine on the release of acetylcholine were examined. Electrical stimulation produced an in-crease in [^3H]acetylcholine release from the striatal slices. Exposure of the slices to nicardipine significantly inhibited the stimulation-evoked [3H] acetylcholine release. An endogenous excitatory amino acid, L-glutamate, also elicited release of [^3H]acetylcholine. Nicardipine significantly reduced the L-glutamate-induced release of [^3H]acetylcholine, and the effect was pronounced in the presence of Mg^<2+>. These results demonstrate that nicardipine inhibits both electrically and chemically stimulated [^3H]acetylcholine release from rat striatum. The ability of nicardipine to inhibit cholinergic transmission may be related to the central effect of this Ca^<2+> channel blocker.

• 社団法人日本循環器学会の論文
• 1993-09-20

著者

• Nishio Ichiro

  Division Of Cardiology Department Of Medicine Wakayama Medical College

• Nishio Ichiro

  Division Of Cardiology Department Of Internal Medicine Wakayama Medical College

• MASUYAMA Yoshiaki

  Tokyo Rousai Hospital

• Tsuda Kazushi

  Department Of Cardiovascular Medicine

• Tsuda Kazushi

  Neurochemistry Research Unit New York University Medical Center School Of Medicine

• TSUDA SEIKO

  Neurochemistry Research Laboratories New York University Medical Center

• Tsuda Seiko

  Neurochemistry Reseach Laboratories New York University Medical Center

• Tsuda Kazushi

  Internal Medicine Division Of Cardiovascular Medicine Wakayama Medical University

• Masuyama Yoshiaki

  Tokyo Rosai Hospital

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