Sex Difference in Development of Fetal Pituitary-Gonadal Axis : Histologic Observations on the Anterior Pituitary in Fetal Rats Gonadectomized <I>in utero</I>
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概要
- 論文の詳細を見る
Male and female fetal rats were gonadectomized <I>in utero</I> on the 20th day of gestation. Two days after the operation, the pituitaries were observed histologically in order to examine the changes of the population of basophilic cells. The gonadectomy of a male fetus caused a significant increase in the per cent of basophilic cells, whereas that of a female fetus induced no significant change. Since the increase in the relative number of basophilic cells following gonadectomy has already been accepted to be intimately related to the increased production of gonadotrophic hormones, the present results strongly suggest that the feedback mechanism between the pituitary and the gonad is already operated before birth in males but not in females. There is a definite sex difference in development of the pituitary-gonadal axis during the fetal life.
- 社団法人 日本内分泌学会の論文
著者
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Nakai Toshiaki
Department Of Clinical Pathology University Of Tsukuba
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Sakamoto Shoichi
Department Of Applied Physics Seikei University
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Eguchi Yasunobu
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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KIGAWA Tomonori
Department of Obstetrics and Gynecology, Oita Medical College
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Kigawa Tomonori
Department Of Obstetrics And Gynecology Faculty Of Medicine University Of Tokyo Tokyo
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Sakamoto Shoichi
Department Applied Physics Seikei University
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NAKAI TOSHIAKI
Department of Clinical Pathology and Metabolism, Dokkyo University School of Medicine
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