Urinary Excretion of D-Serine in Human : Comparison of Different Ages and Species
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概要
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The urinary excretion of D-serine (D-Ser) in human, rat and dog of various ages was studied. Great amounts of D-Ser were consistently excreted in human urine throughout life. No age-dependent changes were observed in urinary D-Ser/total-Ser ratios from the newborn to the aged. D-Ser/creatinine ratios in adult human urine were found to be relatively constant in individuals. The constant excretion of D-Ser in human urine was confirmed by analyzing the consecutive 24 h urine of three volunteers. High concentrations of D-Ser and D-alanine (D-Ala) were found in adult dog urine. The urinary D-Ser concentration was high in young rats at unweaned and weaned periods, and then declined with increasing age. In contrast, the urinary D-Ala concentration was very low in suckling rats, and increased rapidly after the weaned state and then declined with increasing age. The species- and age-related excretion of D-Ser in mammalian urine is considered to be due to the differences in the renal handing of D-Ser, because plasma D-Ser concentrations among the groups were not so different. Although free D-Ser has been detected in animal foods and human colostrum, the amount is insufficient to explain the concentration of D-Ser found in urine. These results indicate that urinary D-Ser in mammals may be mainly of endogenous origin.
- 公益社団法人日本薬学会の論文
- 1998-02-15
著者
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今井 公江
Faculty Of Pharmaceutical Sciences Setsunan University
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Huang Yong
東京大学 大学院
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Imai K
Univ. Tokyo Tokyo Jpn
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SATOH Kazuo
Department of Electronic Engineering, Faculty of Engineering, Osaka University
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Santa T
Univ. Tokyo Tokyo Jpn
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Santa Tomofumi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Santa Tomofumi
Department Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of
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Nishikawa T
Kitasato Laboratory Sumitomo Metal Bio-science Inc.
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HUANG Yong
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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NISHIKAWA Takashi
Kitasato Laboratory, Sumitomo Metal Bio-Science, Inc.,
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IWATA Tsutomu
Department of Pediatrics, Mejirodai Campus, Faculty of Medicine, The University of Tokyo
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FUKUSHIMA Takeshi
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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HOMMA Hiroshi
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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IMAI Kazuhiro
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Imai K
Department Of Chemistury Faculty Of Science Tokyo University Of Science
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Fukushima Takeshi
Department Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences Thc University Of
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Fukushima Takeshi
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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Imai Kazuhiro
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Huang Yong
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Huang Yong
Institute Of Acoustics Chinese Academy Of Science
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Homma H
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Homma H
Kyoritsu Coll. Pharmacy Tokyo Jpn
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Imai K
Department Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of
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Iwata Tsutomu
Departmennt Of Pediatrics Mejirodai Campus University Of Tokyo
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Nishikawa Takashi
Kitasato Laboratory Sumitomo Metal Bio-science Inc.
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