A COMPARISON OF URIDINE DIPHOSPHATE-GLUCURONOSYL-TRANSFERASE AND OTHER DRUG METABOLIZING ENZYME ACTIVITIES BETWEEN TWO MUTANT STRAINS OF WISTAR RATS WITH A GENETIC DEFICIENCY IN BILIRUBIN OR ANDROSTERONE GLUCURONIDATION
スポンサーリンク
概要
- 論文の詳細を見る
A jaundiced rat strain was derived from a cross between Gunn and Wistar-Imamichi rats, and inbreeding was continued by forced heterozygosis with jaundice locus. These Gunn rats have black pigment on heads and a black stripe on their backs similar to Long-Evans rats. Wistar rats with low activity in androsterone (AD) glucuronidation were selected and inbred (LA Wistar rats). The levels of hepatic uridine diphosphate-glucuronosyltransferase (GT) and sulfotransferase (ST) activities as well as cytochrome P-450 contents were compared in these mutant strains. Gunn rats were devoid of bilirubin (BL) GT activity but had high AD GT activity. LA Wistar rats had very low AD GT activity but showed high BL GT activity. Native and Triton X-100-stimulated GT activities toward 2-aminophenol and 4-nitrophenol (NP) were much lower in Gunn rats than in LA Wistar rats. When N-nitrosodiethylamine was added to the incubation media, these GT activities were stimulated equally to high levels in both mutants. N-Nitrodiethylamine provided a similar stimulatory effect on NP GT activity. There were no significant differences in ST activities toward cortisol, AD and NP and cytochrome P-450 contents in the two mutant strains. These results indicate that Gunn and LA Wistar rats have a different deficiency in GT isoenzymes.
著者
-
HOMMA Hiroshi
Graduate School of Pharmaceutical Sciences, The University of Tokyo
-
NAGAI Fusako
Kyoritsu College of Pharmacy
-
Nagai F
Kyoritsu College Of Pharmacy
-
Homma H
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
-
Homma H
Kyoritsu Coll. Pharmacy Tokyo Jpn
-
MATSUI Michio
Kyoritsu College of Pharmacy
-
Takahashi M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
-
Takahashi Mie
Kyoritsu College Of Pharmacy
-
Tanase Hisao
Kyoritsu College Of Pharmacy:laboratory Animal Science And Toxicology Laboratories Sankyo Company Lt
-
HOMMA Hiroshi
Kyoritsu College of Pharmacy
関連論文
- Urinary Excretion of D-Serine in Human : Comparison of Different Ages and Species
- Simultaneous Measurement of Changes in the Concentration and Localization of Calcium and Actin in Migrating Neutrophils Using a Confocal Laser Scanning Microscope
- Age-Related Weakening of Baroreflex-Mediated Sympathetic Activity in Spontaneously Hypertensive Rats in Response to Blood Pressure Reduction
- Comparison of the Sympathetic Nervous System Activity between Spontaneously Hypertensive and Wistar-Kyoto Rats to Respond to Blood Pressure Reduction
- Liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric determination of anandamide and its analogs in rat brain and peripheral tissues
- Effect of Icaria Chemotactic Peptide and Its Analogue on the Intracellular Calcium Changes in Guinea Pig Neutrophils
- Optimization of the Reaction Conditions for the Peroxyoxalate Chemiluminescence Detection System of Fluorescent Compounds in a High-Performance Liquid Chromatography
- Generation of an Active Intermediate(s)during the Storage of a Peroxyoxalate Chemiluminescence Reagent Solution under the Presence of Strong Carboxylic Acids
- A New Mutant Strain of Gunn-LA Wistar Rats with Genetic Deficiencies in Bilirubin and Androsterone Uridine Diphosphate-Glucuronosyltransferases
- A COMPARISON OF URIDINE DIPHOSPHATE-GLUCURONOSYL-TRANSFERASE AND OTHER DRUG METABOLIZING ENZYME ACTIVITIES BETWEEN TWO MUTANT STRAINS OF WISTAR RATS WITH A GENETIC DEFICIENCY IN BILIRUBIN OR ANDROSTERONE GLUCURONIDATION
- Cytochrome P450 (CYP) Expression in Human Myeloblastic and Lymphoid Cell Lines
- Expression Profiling of Sulfotransferases in Human Cell Lines Derived from Extra-Hepatic Tissues
- Identification and Purification of Sulfotransferases for 20-Hydroxysteroid from the Larval Fat Body of a Fleshfly, Sarcophaga peregrina(Biochemistry & Molecular Biology)
- Behavioral and Pharmacological Studies on Gluten Exorphin A5, a Newly Isolated Bioactive Food Protein Fragment, in Mice
- Effects of Tyr-MIF-1 on Stress-Induced Analgesia and the Blockade of Development of Morphine Tolerance by Stress in Mice
- Inhibitory Effects of Green Tea and Grape Juice on the Phenol Sulfotransferase Activity of Mouse Intestines and Human Colon Carcinoma Cell Line, Caco-2
- Oxidative Stress Induces GSTP1 and CYP3A4 Expression in the Human Erythroleukemia Cell Line, K562 (Biochemistry/Molecular Biology)
- A Non-opioid Mechanism in the Inhibitory Effect of Ginseng Saponins on Electrically Evoked Contractions of Guinea-Pig Ileum and Mouse vas Deferens
- Effects of Gonadal Hormones on the Zonal Expression of Rat Hepatic Phenol Sulfotransferases
- RAT LIVER SULFOTRANSFERASES : EFFECTS OF GONADAL HORMONES AND OTHER FACTORS ON ENZYME ACTIVITIES
- Changes in the Expression of Cytochrome P450 Genes in Hemin-Induced Differentiated K562 Cells(Biochemistry)
- Sulfortransferases in a Human Colon Carcinoma Cell Line, Caco-2
- Molecular Cloning, Expression and Characterization of a Phenol Sulfotransferase cDNA from Mouse Intestine
- A Potent Mu-Opioid Receptor Agonist, Dihydroetorphine, Fails to Produce the Conditioned Place Preference in Mice
- Antinociceptive Effect of Dihydroetorphine Following Various Routes of Administration : a Comparative Study with Morphine
- Further Evidence for the Participation of an α_2-Adrenoceptor Mediated Mechanism in the Production of Forced Swimming-Stress Induced Analgesia in Mice
- PARTICIPATION OF AN α2-MEDIATED MECHANISM IN THE PRODUCTION OF FORCED SWIMMINGSTRESS INDUCED ANALGESIA IN MICE
- The Opioid Activity and Receptor Selectivity of Fluorinated Leu^5 Enkephalin Analogues in Vitro and in Vivo
- The Opioid Receptor Selectivity for Trimebutine in Isolated Tissues Experiments and Receptor Binding Studies
- Selectivity for Opioid Receptor Subtypes of Enkephalin Analogues in Isolated Smooth Muscle and in the Analgesic Effect in Mice
- Distinctive Effect of Ginseng Saponins on Development of Morphine Tolerance in Guinea-Pig Ileum and Mouse vas Deferens
- Studies on the fate of D-aspartic acid in pineal and pituitary glands of rats after intravenous administration
- HETEROGENEITY OF RAT LIVER SULFOTRANSFERASES
- Implication of ATP-Sensitive K^+ Channels in Various Stress-Induced Analgesia (SIA) in Mice
- THE MORPHINE 3-GLUCURONIDE DIRECTED ANTIBODY: ITS IMMUNOLOGICAL SPECIFICITY AND POSSIBLE USE FOR RADIOIMMUNOASSAY OF MORPHINE IN URINE
- GENETIC DEFECT OF URIDINE DIPHOSPHATE-GLUCURONOSYLTRANSFERASE ISOENZYME
- RADIOIMMUNOASSAY OF METHIONINE ENKEPHALIN AND INTERFERENCE BY BRAIN FACTOR OF IMMUNOREACTIVITY AND OPIATE RECEPTOR BINDING ACTIVITY
- URINARY EXCRETION PATTERNS OF MORPHINE IN HUMANS FOLLOWED BY AN RADIOIMMUNOASSAY METHOD
- Identification of Three Hydroxysteroid Sulfotransferase Isoenzymes in the Rat Liver
- MULTIPLE FORMS AND A DEFICIENCY OF URIDINE DIPHOSPHATE-GLUCURONOSYLTRANSFERASES IN WISTAR RATS
- Effects of Phenolic Environmental Estrogens on the Sulfotransferase Activity of the Mouse Intestine and a Human Colon Carcinoma Cell Line, Caco-2
- Enantiomeric Separation of NBD-Amino Acids by Capillary Zone Electrophoresis Using Cyclodextrins as Chiral Selectors