RADIOIMMUNOASSAY OF METHIONINE ENKEPHALIN AND INTERFERENCE BY BRAIN FACTOR OF IMMUNOREACTIVITY AND OPIATE RECEPTOR BINDING ACTIVITY

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概要

• 論文の詳細を見る

• We developed a radioimmunoassay of methionine-enkephalin (met-enk) which was found to be highly specific to the peptide and I pmole was the detection limit. Interference by the following peptides was practically negligible; leucine-enkephalin, LAP- or CNBr-treated met-enk, α- and β-endorphins. Morphine and its congeners were totally inert. Measurement of met-enk in rat brain P<SUB>2</SUB> fraction revealed besides met-enk, the presence of the factor which cross-reacted with the antiserum and also appeared to bind with the brain opiate receptor. Though the nature of the factor has not yet been characterized, it is suggested that for qualitative assessment of the tissue level of met-enk, a method to selectively inactivate either the peptide or the factor should be developed first.

• 社団法人 日本薬理学会の論文

著者

• Ueno Eiko

  Department Of Pharmacology Kyoto Prefectural University Of Medicine

• Yajima Haruaki

  Faculty Of Pharmaceutical Sciences Kyoto University

• Ogawa Hiroshi

  Faculty of Science and Engineering, Saga university

• Koida Masao

  Department Of Parmacology Setsunan University

• WATANABE Joe

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

• Takahashi M

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University

• Takahashi Masakatsu

  Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University

• Kaneto Hiroshi

  Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University

• Ogawa Hiroshi

  Faculty Of Human And Cultural Studies Tezukayamagakuin University

• UENO Eiko

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

• OGAWA Hiroshi

  Faculty of Pharmaceutical Sciences, Kyoto University

• YAJIMA HARUAKI

  Faculty of Pharmaceutical Science, Kyoto University

• Takahashi Masakatsu

  Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University

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