Histomorphometrical Evaluation of Anti-Osteopenic Effect of Nasal Salmon Calcitonin in a Type 1 Osteoporotic Model of Rats
スポンサーリンク
概要
- 論文の詳細を見る
It was examined histomorphometrically whether or not and how chronic treatment with nasal salmon calcitonin (SCT) of rats could prevent ovariectomy (OVX)-induced osteoporotic changes in the trabecular bone of tibia. During 7 weeks on a synthetic low Ca diet after OVX, rats developed type 1 osteopenia which was defined by strut analysis as resulting mainly from loss in the connectivity of strut but in the thickness. An intermittent dosing regimen of nasal SCT (10 or 40U/rat/d, 3d/week, for 7 weeks) was able to retard development of osteopenia in a dose-dependent manner. The results indicate that the nasal route would be usable for chronic treatment of experimental osteoporosis with SCT and possibly other peptide anti-osteoporotics.
- 公益社団法人日本薬学会の論文
- 1996-02-15
著者
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NAKAMUTA HIROMICHI
Department of Parmacology, Setsunan University
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KOIDA MASAO
Department of Parmacology, Setsunan University
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HOSHINO Tomomi
Faculty of Pharmaceutical Sciences Toyama Medical and Pharmaceutical University
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HOSHINO Takashi
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
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Hoshino T
Takeda Chemical Industries Ltd. Osaka Jpn
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Koida M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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Koida Masao
Department Of Parmacology Setsunan University
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NITTA Takaya
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University
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Nitta T
Setsunan Univ. Osaka Jpn
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新田 東洋彦
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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Nakamuta H
Department Of Pharmacology Hiroshima International University
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Nakamuta Hiromichi
Department Of Parmacology Setsunan University
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Hoshino Takashi
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University:(present Address)niiga
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