Phosphate Stimulates Differentiation and Mineralization of the Chondroprogenitor Clone ATDC5
スポンサーリンク
概要
- 論文の詳細を見る
ATDC5 cells were employed to examine how inorganic phosphate (Pi) influences chondrocytic bone formation. 1) Pi (3 - 30 mM) plus ascorbic acid (50 μg/ml) dose-dependently accelerated proliferative differentiation and mineralization of ATDC5. 2) Northern blot analysis revealed that 10 mM Pi suppressed expression of type II collagen and PTH (parathyroid hormone) / PTH-related peptide (PTHrP) receptor, while it accelerated type X collagen expression. 3) Pi (3 - 30 mM) dose-dependently increased luciferase activity in the cells transfected with 3000 bp type X collagen promoter fused to the luciferase gene. The results suggest a regulatory role of Pi in endochondral osteogenesis.
- 社団法人 日本薬理学会の論文
- 2001-03-01
著者
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Fujita Takashi
Department Of Cardiology Kanazawa University
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NAKAMUTA HIROMICHI
Department of Parmacology, Setsunan University
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KOIDA MASAO
Department of Parmacology, Setsunan University
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Fujita T
Division Of Oral Cytology And Cell Biology Department Of Developmental And Reconstructive Medicine N
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FUJITA Takuya
Ritsumeikan University College of Information Science and Engeneering
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FUKUYAMA Ryo
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University
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IZUMO Nobuo
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University
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MEGURO Toru
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University
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YASUTOMI Chigusa
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University
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Fujita T
Ritsumeikan University College Of Information Science And Engeneering
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Izumo Nobuo
Department Of Pharmacology Daiichi College Of Pharmaceutical Sciences
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Meguro Toru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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Meguro Toru
Department Of Pathology Yamagata University School Of Medicine
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Koida M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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Koida Masao
Department Of Parmacology Setsunan University
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Fukuyama Tohru
Department Of Pharmacology Hiroshima International University
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Fukushima Tohru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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Nakamuta H
Department Of Pharmacology Hiroshima International University
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Nakamuta Hiromichi
Department Of Parmacology Setsunan University
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Fujita Takashi
Department Of Breast Oncology Aichi Cancer Center Hospital
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Fujita Takashi
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
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Fujita Takashi
Department Of Biochemistry The University Of Sydney
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Yasutomi Chigusa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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Fujita Takashi
Department Of Anesthesiology Suwa Red Cross Hospital
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