Bone-anabolic Effect of Salmon Calcitonin on Glucocorticoid-Induced Osteopenia in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The anabolic effect of salmon calcitonin (SCT) on skeletal tissue was examined on glucocorticoid-induced osteopenia in female rats (12 weeks old). By the administration of methylprednisolone acetate (MPA : 0.1 mg/kg, s.c., 3 times/week) for 8 weeks, histomorphometrically detectable osteopenia with the characteristics of decreased bone formation and increased bone resorption developed in proximal tibia metaphysis. Serum osteocalcin level was also decreased by MPA treatment. Subsequent treatment with SCT (10 U/kg, s.c., 5 times/week) was found to reverse once developed osteopenia with the return of the osteocalcin level, though rats were still on MPA. Histomorphometry revealed that SCT decelerated bone resorption but augmented bone formation in this osteopenic model. Affer a single injection of SCT (2.5 U/kg-40 U/ke, s.c.), the serum level of parathyroid hormone (PTH) which had a potent anabolic on bone formation increased in a dose-dependent manner. These results indicate that SCT has a stimulating effect on osteoblastic bone formation and this anabolic effect may at least in part be due to its indirect effect to increase endogenous PTH secretion.
- 社団法人日本薬学会の論文
- 2000-08-01
著者
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Fujita Takashi
Department Of Cardiology Kanazawa University
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NAKAMUTA HIROMICHI
Department of Parmacology, Setsunan University
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KOIDA MASAO
Department of Parmacology, Setsunan University
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Fujita T
Division Of Oral Cytology And Cell Biology Department Of Developmental And Reconstructive Medicine N
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FUJITA Takuya
Ritsumeikan University College of Information Science and Engeneering
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FUKUYAMA Ryo
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University
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IZUMO Nobuo
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University
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FURUICHI Hiroshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University
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KOHNO Takeyuki
Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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Takeuchi Kenji
福井医科大学 微生物
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Fujita T
Ritsumeikan University College Of Information Science And Engeneering
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Izumo Nobuo
Department Of Pharmacology Daiichi College Of Pharmaceutical Sciences
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Koida M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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Koida Masao
Department Of Parmacology Setsunan University
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Fukuyama Tohru
Department Of Pharmacology Hiroshima International University
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Kohno Takeyuki
Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Fukushima Tohru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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Nakamuta H
Department Of Pharmacology Hiroshima International University
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Furuichi H
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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Furuichi Hiroshi
Department Of Mechanical Engineering Faculty Of Engineering Osaka City University
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Nakamuta Hiromichi
Department Of Parmacology Setsunan University
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Fujita Takashi
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
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Fujita Takashi
Department Of Biochemistry The University Of Sydney
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Fujita Takashi
Department Of Anesthesiology Suwa Red Cross Hospital
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