PROTEIN SYNTHESIS IN MOUSE BRAIN DURING DEVELOPMENT OF ACUTE MORPHINE TOLERANCE
スポンサーリンク
概要
- 論文の詳細を見る
In order to observe the effects of morphine on protein metabolism in mouse brain, experimental procedures were carried out over a 7 hr period of infusion. When the analgesia reached a peak, namely around 2 hr after the start of infusion, the <I>in vivo</I> incorporation of radioactive leucine into protein estimated by the dual label technique was uniformally depressed in all the examined subcellular fractions of both brain and liver. After tolerance developed, however, the incorporation of leucine increased to a much higher level than the control in brain subcellular fractions and the increase was masked by naloxone. In contrast, the incorporation into a TCA soluble fraction of the brain S<SUB>2</SUB>, separated by Gray and Whittakers method, was more than doubled even after 4 hr infusion. While the <I>in vitro</I> incorporation rate of the mitochondrial fraction significantly fluctuated during development of tolerance with naloxone that of the synaptosomal fraction did not fluctuate. The observed coincidence in the time course of development of tolerance and changes in the brain protein synthesis indicates a possible relationship between the phenomena, though the causal nature of the relationship could not be elucidated.
- 社団法人 日本薬理学会の論文
著者
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Sasano Hiroshi
Department Of Anesthesiology And Medical Crisis Management Nagoya City University Graduate School Of
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KANETO Hiroshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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Nakajima Tohru
Department Of Chemical System Engineering School Of Engineering University Of Tokyo
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Koida Masao
Department Of Parmacology Setsunan University
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
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Nakajima Tohru
Department Of Chemical System Engineering Graduate School Of Engineering University Of Tokyo
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NAKAJIMA Tohru
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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