<I>EX VIVO</I> <SUP>3</SUP>H-SPIROPERIDOL BINDING TO RAT STRIATUM AND THE INHIBITORY EFFECTS OF NEUROLEPTICS
スポンサーリンク
概要
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Neuroleptic drugs were given to rats and at different time intervals the animals were decapitated and <SUP>3</SUP>H-spiroperidol binding to the striatal homogenates was determined <I>in vitro</I>. Two hours after an intraperitoneal administration of spiroperidol, perphenazine, haloperidol, chlorpromazine or thioridazine in doses of 0.03-30 mg/kg, <SUP>3</SUP>H-spiroperidol binding to the striatal homogenates was inhibited dose-dependently with an ID50 value of 0.11, 0.23, 1.1, 3.7 or 9.4 mg/kg, respectively. After a single intramuscular administration of fluphenazine enanthate (10 mg/kg), a longacting neuroleptic drug, long-lasting inhibitory effect (over 4 weeks) on the binding was also observed. These results indicate that <I>ex vivo</I> <SUP>3</SUP>H-spiroperidol binding method may be useful to measure the duration and the potency of anti-dopaminergic activities of drugs.
- 社団法人 日本薬理学会の論文
著者
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Nakajima Tohru
Department Of Chemical System Engineering School Of Engineering University Of Tokyo
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KURUMA ISAMI
Department of Biochemistry, Nippon Roche Research Center
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EGAWA Emiko
Department of Pharmacology, Nippon Roche Research Center
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Nakajima Tohru
Department Of Chemical System Engineering Graduate School Of Engineering University Of Tokyo
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KURUMA Isami
Department of Pharmacology, Nippon Roche Research Center
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NAKAJIMA Tohru
Department of Pharmacology, Nippon Roche Research Center
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