CHARACTERIZATION WITH <SUP>3</SUP>H-HALOPERIDOL OF THE DOPAMINE RECEPTOR IN THE RAT KIDNEY PARTICULATE PREPARATION

スポンサーリンク

概要

• 論文の詳細を見る

• The dopamine receptor of rat kidney particulate preparation was identified and characterized by the use of <SUP>3</SUP>H-haloperidol binding. Binding of <SUP>3</SUP>H-haloperidol to the kidney particulate preparation was slow and saturable. The dissociation constants (K<SUB>D</SUB>) were 0.41 nM and 5.88 nM, respectively, according to the model of two classes of independent binding sites. Maximal binding of high affinity site was obtained with 166 fmole/mg protein which was about 40% of the total receptor density. A wide variety of neuroleptics at specifically low concentrations in nanomolar range inhibited the <SUP>3</SUP>H-haloperidol binding. There was an excellent correlation between the affinity of numerous neuroleptics for the kidney particulate preparation and that for the brain striatum.

• 社団法人 日本薬理学会の論文

著者

• Nakajima Tohru

  Department Of Chemical System Engineering School Of Engineering University Of Tokyo

• KURUMA ISAMI

  Department of Biochemistry, Nippon Roche Research Center

• Nakajima Tohru

  Department Of Chemical System Engineering Graduate School Of Engineering University Of Tokyo

関連論文

• Elementary Surface Reaction Simulation of Aluminum Chemical Vapor Deposition from Dimethylaluminumhydride Based on Ab Initio Calculations : Theoretical Process Optimization Procedure(2)
• Determination of 5-Fluorouracil in Plasma and Liver after Oral Administration of 5'-Deoxy-5-Fluorouridine Using Gas Chromatography-Mass Spectrometry
• Successful Transcatheter Coil Embolization of Coronary Artery to Left Ventricular Fistula Associated With Absent Pulmonary Valve With Tricuspid Atresia in Early Infancy
• Idiopathic arterial calcification in infancy with twin-twin transfusion syndrome
• METABOLIC FATE OF TENOXICAM AND A POSSIBLE MECHANISM OF ANTI-INFLAMMATORY ACTIVITY
• CHARACTERIZATION WITH 3H-HALOPERIDOL OF THE DOPAMINE RECEPTOR IN THE RAT KIDNEY PARTICULATE PREPARATION
• EX VIVO 3H-SPIROPERIDOL BINDING TO RAT STRIATUM AND THE INHIBITORY EFFECTS OF NEUROLEPTICS
• PROTEIN SYNTHESIS IN MOUSE BRAIN DURING DEVELOPMENT OF ACUTE MORPHINE TOLERANCE
• The Surface Reaction Mechanism on Al(111)
• Effects of clonidine, .ALPHA.-methyldopa and hydralazine on met-enkephalinergic neurons in cerebral nuclei of spontaneously hypertensive rats.

スポンサーリンク