Distinctive implication of emotional factors in various types of stress-induced analgesia.
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概要
- 論文の詳細を見る
Diazepam, an antianxietic agent, antagonized the stress-induced analgesia (SIA) distinctively depending on the characteristics of the stress. Psychological (PSY, using communication box)-SIA was completely blocked by 1 or 2 mg/kg of diazepam in the tail pinch (TP) method, but not antagonized by 1 mg/kg of the drug in the tail flick test. Swimming-SIA was resistant to diazepam in both methods, and footshock-SIA was only suppressed slightly by 2 mg/kg in the TP method. Thus, emotional factors play an essential role in the production of PSY-SIA, although the participation of the factors in the other SlAs can not be excluded.
- 公益社団法人 日本薬理学会の論文
著者
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Tokuyama Shogo
Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences
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Takahashi Masakatsu
Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
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