PARTICIPATION OF AN α2-MEDIATED MECHANISM IN THE PRODUCTION OF FORCED SWIMMINGSTRESS INDUCED ANALGESIA IN MICE
スポンサーリンク
概要
- 論文の詳細を見る
In mice, both swimming-stress induced analgesia (SW-SIA) and clonidine (CLO) analgesia were dose dependently antagonized by yohimbine, an α2-adrenoceptor antagonist, but not by naloxone, an opioid μ-antagonist. SW-SIA was potentiated by subanalgesic dose of CLO, and CLO analgesia was enhanced by SW-SIA. Animals tolerant to CLO analgesia were tolerant to SW-SIA, in contrast, CLO analgesia was potentiated in SW-SIA tolerant mice. Thus, SW-SIA and CLO analgesia partially share a common α2-adrenergic-dependent mechanism, for their production.
- 公益社団法人日本薬学会の論文
著者
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Tokuyama S
長崎大学 薬 分子薬理
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Tokuyama Shogo
Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences
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KANETO Hiroshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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KANETO Hiroshi
Emeritus Professor, Nagasaki University
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Takahashi M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Takahashi Masakatsu
Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University
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Kaneto H
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
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Takahashi Masakatsu
Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University
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