Possible Role of Nitric Oxide in Anxiety Following Transient Cerebral Ischemia in Mice
スポンサーリンク
概要
- 論文の詳細を見る
The possible role of nitric oxide (NO) in anxiety following transient cerebral ischemia by a 10-min bilateral carotid occlusion was examined in mice. Two days after the ischemia, mice showed a significant decrease in time spent on the open arms in the elevated plus-maze test; and likewise, they showed shortened social interaction time in the social interaction test, suggesting the induction of anxiety. Such anxiety behavior, however, was diminished 7 days after the treatment in both tests. A nonselective nitric oxide synthase (NOS) inhibitor, N ω-nitro-<sc>L</sc>-arginine methyl ester (<sc>L</sc>-NAME), and a selective inducible NOS (iNOS) inhibitor, S-ethylisothiourea (EIT), given twice after reperfusion, produced an anxiolytic effect in the elevated plus-maze test 2 days after the ischemia, while only the former produced antianxiety in the social interaction test. A relatively selective neuronal NOS (nNOS) inhibitor, 7-nitroindazole (7-NI), failed to decrease the level of anxiety in both tests. These results suggest that the production of NO participates in the anxiogenic behavior by the ischemia. Furthermore, NO generated by endothelial NOS (eNOS) or eNOS with iNOS, with no involvement of nNOS, plays an important role in the anxiety induced by the ischemia. Thus, we conclude that 10-min bilateral carotid occlusion provides a useful exploratory animal model for anxiety following transient cerebral ischemia.
- 社団法人 日本薬理学会の論文
- 2003-01-01
著者
-
Nakashima K
Nagasaki Univ. Nagasaki Jpn
-
Nakashima Kenichiro
Department Of Analytical Research For Pharmacoinformatics Graduate School Of Pharmaceutical Sciences
-
Takahashi M
Nagasaki Univ. Nagasaki Jpn
-
Nakashima Mihoko
Department Of Analytical Research For Pharmacoinformatics Graduate School Of Pharmaceutical Sciences
-
Ajiki Ken-ichi
Department Of Analytical Research For Pharmacoinformatics Graduate School Of Pharmaceutical Sciences
-
K. NAKASHIMA
Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Science
-
Takahashi Masakatsu
Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University
-
Ajiki Kenichi
Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University
関連論文
- Development and Application of Sensitive Methods with Luminescence Detections for Determination of Biologically Active Compounds
- A Simple HPLC-fluorescence Method for Quantitation of Curcuminoids and Its Application to Turmeric Products
- Study on the Timing of Degassing for Reproducible Preparation of Polymer-Based Monolithic Columns
- Analytical Studies on the Development of High-Performance Liquid Chromatographic Methods with Fluorescence or Chemiluminescence Detections and Their Practical Applications
- Retrospective Analyses of Atmospheric Polycyclic and Nitropolycyclic Aromatic Hydrocarbons in an Industrial Area of a Western Site of Japan
- Study on Use of Non-steroidal Anti-inflammatory Drugs (NSAIDs) in Chikugo City Hospital with a View to Promoting Rational Drug Use (1)
- Determination of Hydroxylated Polycyclic Aromatic Hydrocarbons in Airborne Particulates by High-Performance Liquid Chromatography with Fluorescence Detection
- Determination of polycyclic aromatic hydrocarbons in milk samples by high-performance liquid chromatography with fluorescence detection
- A simple monitoring method of triazolam metabolism with ethanol-treated rat liver microsomes by the HPLC-UV detection for the preliminary examination of abused drugs interaction
- Determination of organic peroxides by liquid chromatography with on-line post-column ultraviolet irradiation and peroxyoxalate chemiluminescence detection
- A Simple HPLC-Fluorescence Detection of Nitric Oxide in Cultivated Plant Cells by in situ Derivatization with 2,3-Diaminonaphthalene
- A Simple High-performance Liquid Chromatographic Method with UV Detection for the Determination of Fluoropyrimidines in Human Serum
- Development of sensitive high-performance liquid chromatography with fluorescence detection using 4-(4, 5-diphenyl-1H-imidazol-2-yl)-benzoly chloride as a labeling reagent for determination of bisphenol A in plasma samples
- Separation of Sympathomimetic Amines of Abuse and Related Compounds by Micellar Electrokinetic Chromatography
- Simultaneous Determination of Phenolic Xenoestrogens by Solid-Phase Extraction and High-Performance Liquid Chromatography with Fluorescence Detection
- Investigation on the Useful Components in Katsuobushi Residue by an Enzymatic Treatment
- Pursuit of Reaction Process of 4-Nitrotoluene with Potassium t-Butoxide in N, N-Dimethylformamide in the Presence of Air by High-Performance Liquid Chromatographic Methods with UV and Three-Dimensional Photodiode Array-UV Detections
- Measurement and Assessment of Air Pollutants(2)(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Preliminary Study on the Development of HPLC-fluorescence Determination of Phenolic Compounds as Endocrine Disrupting Chemicals(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- A Simple and Selective Monitoring Method for Nitric Oxide Capturing Ability by HPLC-Fluorescence Detection with 2, 3-Diaminonaphthalene as a Fluorogenic Reagent
- A Sensitive and Rapid FIA with an Immobilized Enzyme Column Reactor and Peroxyoxalate Chemiluminescence Detection for the Determination of Total D-Amino Acids in Human Plasma
- Liquid chromatography studies on the pharmacokinetics of phentermine and fenfluramine in brain and blood microdialysates after intraperitoneal administration to rats
- Fluorometric determination of DL-fenfluramine, DL-norfenfluramine and phentermine in plasma by achiral and chiral high-performance liquid chromatography
- Stereoselective HPLC assay of donepezil enantiomers with UV detection and its application to pharmacokinetics in rats
- Histologicak Evience for Neuroprotective Action of Nebracetam on Ischemic Neuronal Injury in the Hippocampus of Stroke-Prone Spontaneously Hypertensive Rats
- Role of CXC chemokines in ventilator-induced lung injury in rats
- Concentration and characteristics of polychlorinated biphenyls in the sediments of sea and river in Nagasaki Prefecture, Japan
- Heat Shock Protein 70B mRNA Expression in L929 Cells Attached on Lipid Films
- Maximal Inspiratory Flow with Nasal Continuous Positive Airway Pressure in Patients with Sleep-Disordered Breathing : Relevance to the Upper Airway Reflex
- Detection of Inspiratory Flow Limitation with Cardiogenic Flow Oscillation in Patients with Obstructive Sleep Apnea
- Successful Surgical Treatment of a Solitary Parapharyngeal Metastasis from Thyroid Cancer, Using the Mandibular Swing-Transcervical Approach: Report of a Case
- Local Distribution into Brain Tumor and Pharmacokinetics of 4-Pyridoxate Diammine Hydroxy Platinum, a Novel Cisplatin Derivative, after Intracarotid Administration in Rats with 9L Malignant Glioma : Simultaneous Brain Microdialysis Study
- In Vivo Microdialysis to Determine the Relative Pharmacokinetics of Drugs
- Aspirin Therapy for the Primary Prevention of Cardiovascular Disease : A Meta-analysis of Randomized Trials
- Behavioral and Pharmacological Studies on Gluten Exorphin A5, a Newly Isolated Bioactive Food Protein Fragment, in Mice
- Effects of Tyr-MIF-1 on Stress-Induced Analgesia and the Blockade of Development of Morphine Tolerance by Stress in Mice
- A Non-opioid Mechanism in the Inhibitory Effect of Ginseng Saponins on Electrically Evoked Contractions of Guinea-Pig Ileum and Mouse vas Deferens
- A Potent Mu-Opioid Receptor Agonist, Dihydroetorphine, Fails to Produce the Conditioned Place Preference in Mice
- Antinociceptive Effect of Dihydroetorphine Following Various Routes of Administration : a Comparative Study with Morphine
- Participation of GABAergic Systems in the Production of Antinociception by Various Stresses in Mice
- INVOLVEMENT OF DIFFERENT MECHANISMS, OPIOID AND NON-OPIOID FORMS, IN THE ANALGESIA INDUCED BY FOOTSHOCK (FS) AND IMMOBILIZED-WATER IMMERSION (IW) STRESS
- Further Evidence for the Participation of an α_2-Adrenoceptor Mediated Mechanism in the Production of Forced Swimming-Stress Induced Analgesia in Mice
- PARTICIPATION OF AN α2-MEDIATED MECHANISM IN THE PRODUCTION OF FORCED SWIMMINGSTRESS INDUCED ANALGESIA IN MICE
- The Opioid Activity and Receptor Selectivity of Fluorinated Leu^5 Enkephalin Analogues in Vitro and in Vivo
- The Opioid Receptor Selectivity for Trimebutine in Isolated Tissues Experiments and Receptor Binding Studies
- Selectivity for Opioid Receptor Subtypes of Enkephalin Analogues in Isolated Smooth Muscle and in the Analgesic Effect in Mice
- Distinctive Effect of Ginseng Saponins on Development of Morphine Tolerance in Guinea-Pig Ileum and Mouse vas Deferens
- Effects of Footshock-, Psychological- and Forced Swimming-Stress on the Leaning and Memory Processes: Involvement of Opioidergic Pathways
- INFLUENCES OF MIF AND RELATED PEPTIDES ON THE ACTIONS OF MORPHINE AND PENTOBARBITAL
- Disability of Development of Tolerance to Morphine and U-50,488H, a Selective к-Opioid Receptor Agonist, in Neuropathic Pain Model Mice
- Implication of ATP-Sensitive K^+ Channels in Various Stress-Induced Analgesia (SIA) in Mice
- RADIOIMMUNOASSAY OF METHIONINE ENKEPHALIN AND INTERFERENCE BY BRAIN FACTOR OF IMMUNOREACTIVITY AND OPIATE RECEPTOR BINDING ACTIVITY
- Possible Role of Nitric Oxide in Anxiety Following Transient Cerebral Ischemia in Mice
- ANTIBODIES TO BSA CONJUGATES OF MORPHINE DERIVATIVES: STRICT DEPENDENCY OF THE IMMUNOLOGICAL SPECIFICITY ON THE HAPTEN STRUCTURE
- MORPHINE SPECIFIC SEIZURE INDUCED IN POLY-D-LYSINE PRETREATED MICE AND SOME EVIDENCE SUGGESTING THE PRESENCE OF A NOVEL SITE FOR THE MORPHINE EFFECT
- Comparative studies on morphine- and stress-induced analgesia and the development of tolerance to the effects: Implication of protein synthesis mechanism in the process.
- Differential Roles of the Adrenal Gland in the Suppression of Morphine Antinociceptive Tolerance Development by .ALPHA.- and .BETA.-Adrenergic Blockers.
- Development of Tolerance to Morphine Antinociception in Mice Treated with Nociceptive Stimulants.
- Blockade by Ginseng Extract of the Development of Reverse Tolerance to the Ambulation-Accelerating Effect of Methamphetamine in Mice.
- The role of the catecholaminergic mechanism in foot shock (FS) stress- and immobilized-water immersion (IW) stress-induced analgesia in mice.
- Role of adrenal glucocorticoids in the blockade of the development of analgesic tolerance to morphine by footshock stress exposure in mice.
- Involvement of Pain Associated Anxiety in the Development of Morphine Tolerance in Formalin Treated Mice.
- Anti-Stress Effect of Ginseng on the Inhibition of the Development of Morphine Tolerance in Stressed Mice.
- Blockade of the development of analgesic tolerance to morphine by concurrent treatment with opioid-but not non-opioid-mediated stress in mice.
- Dual action mechanisms of KK-3, a newly synthesized leu-enkephalin derivative, in the production of spinal analgesic effects.
- Blockade of the development of analgesic tolerance to morphine by psychological stress through benzodiazepine receptor mediated mechanism.
- Footshock- and Psychological-Stress Prevent the Development of Tolerance to Spinal but Not Supraspinal Morpine.
- Involvement of Serotonergic Receptor Subtypes in the Production of Antinociception by Psychological Stress in Mice.
- Morphine Dependence With or Without Tolerance in Formalin-Treated Mice: Further Evidence for the Dissociation.