Behavioral and Pharmacological Studies on Gluten Exorphin A5, a Newly Isolated Bioactive Food Protein Fragment, in Mice

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概要

• 論文の詳細を見る

• Central effects of gluten exorphin A5 (Gly-Tyr-Tyr-Pro-Thr), a fragment from wheat gluten, were studied on the pain-inhibitory system, emotionality and learning/memory processes in mice. Orally administered gluten exorphin A5 produced neither an antinociceptive effect nor an effect on morphine analgesia. Intracerebroventricularly (i.c.v.) administered gluten exorphin A5 produced mild but significant antinociception in a dose-dependent manner, while not affecting the morphine analgesia. On the other hand, oral gluten exorphin A5 suppressed the endogenous pain-inhibitory system, i.e., antinociception induced by socio-psychological- (PSY-) stress (SIA) using a communication box; intraperitoneal gluten exorphin A5 abolished both footshock- (FS-) stress-induced antinociception (SIA) and PSY-SIA; and i.c.v. gluten exorphin A5 suppressed FS-SIA, but rather potentiated PSY-SIA. This peptide given by these routes was withuot effect on forced swim-SIA. In addition, oral gluten exorphin A5 tended to prolong the retention time on open arms in the elevated plus-maze test. Finally, oral gluten exorphin A5 when given during the post-training period of learning/memory processes significantly increased the latency into the dark compartment in the one-trail step-though type passive avoidance test, indicating that the peptide also facilitates the acquire/consolidation process of learning/memory. Thus, gluten exorphin A5 has been found to produce various effects no only in the peripheral nervous systems but also in the central nervous system.

• 社団法人 日本薬理学会の論文
• 2000-11-01

著者

• YOSHIKAWA Masaaki

  Research Institute for Food Science, Kyoto University

• TAKAHASHI Masakatsu

  Department of Respiratory Medicine, Kanazawa Medical University

• Yoshikawa Masaaki

  Research Institute For Food Science Kyoto University

• Yoshikawa Masaaki

  Department Of Clinical Pharmacology School Of Medicine Tokai University

• FUKUNAGA Hiroko

  Department of Pharmacoinformatics, School of Pharmaceutical Sciences, Nagasaki University

• KANETO Hiroshi

  Emeritus Professor, Nagasaki University

• FUKUDOME Shin-ichi

  Food Research Laboratory, Nisshin Flour Milling Co., Ltd.

• Fukunaga Hiroko

  Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University

• Takahashi M

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University

• Takahashi Masakatsu

  Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University

• Kaneto Hiroshi

  Emeritus Professor Nagasaki University

• Fukudome Shin-ichi

  Food Research Laboratory Nisshin Flour Milling Co. Ltd.

• Takahashi Masakatsu

  Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University

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