Antinociceptive Effect of Dihydroetorphine Following Various Routes of Administration : a Comparative Study with Morphine
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概要
- 論文の詳細を見る
Using various routes of administration, the antinociceptive effects of dihydroetorphine (DHE) and morphine were measured in mice. Regardless of the route of systemic and local administration, DHE (1-20μg/kg, i.p. ; 1-10μg/kg, s.c. ; 1-10μg/kg, i.v. ; 10-1000μg/kg, p.o. ; 10-100ng/mouse, intracerebroventricularly (i.c.v.) ; and 10-100ng/mouse, intrathecally (i.t.)) and morphine (1-20mg/kg, i.p. ; 1-10mg/kg, s.c. ; 1-10mg/kg, i.v. ; 10-100mg/kg, p.o. ; 1-10μg/mouse, i.c.v. ; and 0.5-3μg/mouse, i.t.) produced an antinociceptive effect in a dose-dependent manner, as evaluated by the tail pinch method. However, the duration of the antinociceptive effect of DHE was shorter than that of morphine. The efficacy ratio of the antinociceptive effect between DHE and morphine was approximately 1000 to 1500 : 1 by parenteral administration (i.p., s.c., or i.v.) and about 100 : 1 by the oral route. Meanwhile, using direct application into the central nervous system (CNS) (i.c.v. or i.t.), the effect of DHE was only 10 to 20 times that of morphine. These data suggest that DHE has an ideal quality as an analgesic by systemic administration which is a more convenient application than local injection, since only a minimum dose of DHE is needed to induce suitable potency of antinociception, and the duration of the effect is short. Further, these unique characteristics of DHE might lead to the prevention of the development of dependence by avoiding accumulation of the drug in the CNS.
- 公益社団法人日本薬学会の論文
- 1996-03-15
著者
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Tokuyama Shogo
Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences
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Tokuyama S
長崎大学 薬 分子薬理
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Tokuyama Shogo
Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences
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KANETO Hiroshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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TAKAHASHI Masakatsu
Department of Respiratory Medicine, Kanazawa Medical University
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NAKAMURA Fumihiro
Department of Psychiatry, Shizuoka Institute of Epilepsy and Neurological Disorders
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KANETO Hiroshi
Emeritus Professor, Nagasaki University
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Takahashi M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Takahashi Masakatsu
Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University
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Kaneto H
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
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Nakamura F
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Nakamura Fumihiro
Department Of Psychiatry Shizuoka Institute Of Epilepsy And Neurological Disorders
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NAKAMURA Fumihiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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Takahashi Masakatsu
Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University
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