Important role of adrenergic function in the development of analgesic tolerance to morphine in mice.
スポンサーリンク
概要
- 論文の詳細を見る
The involvement of a catecholaminergic mechanism in the production of morphine analgesia and the development of tolerance to the effect has been suggested. Here, using various adrenergic blockers, the role of adrenergic function in the mechanism was examined. Phentolamine (α<SUB>1</SUB> + α<SUB>2</SUB>-blocker, 10, 1 and 0.5 mg/kg), prazosin (α<SUB>1</SUB> -blocker, 0.1 and 0.02 mg/kg), propranolol (β<SUB>1</SUB> + β<SUB>2</SUB>-blocker, 10, 1 and 0.5 mg/kg), metoprolol (β<SUB>1</SUB>-blocker, 10 and 1 mg/kg) did not affect morphine analgesia, but dose-dependently suppressed the development of tolerance to morphine. Yohimbine (α<SUB>2</SUB>-blocker, 5 and 1 mg/kg) dose-dependently antagonized morphine analgesia in naive animals and delayed the development of tolerance to morphine. Pindolol (β<SUB>1</SUB> + β<SUB>2</SUB>-blocker but is devoid of membrane stabilizing activity) suppressed the development of tolerance to morphine analgesia; however, d-propranolol, which possesses membrane stabilizing activity but lacks β-blocking activity, could not prevent the development of tolerance. Thus, the suppressive effect of propranolol on the development of tolerance is not due to membrane stabilizing properties. Not only the non-selective adrenergic blockers, phentolamine and propranolol, but also the selective blockers of each receptor subtype, prazosin and metoprolol, suppressed the development of tolerance. This fact may suggest the importance of the equilibrated state of adrenergic functions in the mechanism for the development of tolerance to morphine.
- 公益社団法人 日本薬理学会の論文
著者
-
Kihara Tsuyoshi
Department Of Medicine Yakage Municipal Hospital
-
Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
関連論文
- Xanthostatin, a New Antibiotic(Biological Chemistry)
- NOVEL AND POTENT INHIBITORS SPECIFIC FOR PROLYL ENDOPEPTIDASE AND THEIR ANTI-AMNESIC EFFECT
- SPECIFIC INHIBITORS FOR PROLYL ENDOPEPTIDASE AND THEIR ANTI-AMNESIC EFFECT
- Liposidolide A, a New Antifungal Macrolide Antibiotic
- Additional Case Studies of Human Infestation with Hard Tick (Acarina : Ixodidae) Found in Okayama Prefecture, Japan
- A Non-opioid Mechanism in the Inhibitory Effect of Ginseng Saponins on Electrically Evoked Contractions of Guinea-Pig Ileum and Mouse vas Deferens
- BRAIN LEVEL OF PENTOBARBITAL IS THE PRIMARY DETERMINANT FOR THE DEVELOPMENT OF HYPNOTIC TOLERANCE IN MICE
- A Potent Mu-Opioid Receptor Agonist, Dihydroetorphine, Fails to Produce the Conditioned Place Preference in Mice
- Antinociceptive Effect of Dihydroetorphine Following Various Routes of Administration : a Comparative Study with Morphine
- Participation of GABAergic Systems in the Production of Antinociception by Various Stresses in Mice
- INVOLVEMENT OF DIFFERENT MECHANISMS, OPIOID AND NON-OPIOID FORMS, IN THE ANALGESIA INDUCED BY FOOTSHOCK (FS) AND IMMOBILIZED-WATER IMMERSION (IW) STRESS
- Further Evidence for the Participation of an α_2-Adrenoceptor Mediated Mechanism in the Production of Forced Swimming-Stress Induced Analgesia in Mice
- PARTICIPATION OF AN α2-MEDIATED MECHANISM IN THE PRODUCTION OF FORCED SWIMMINGSTRESS INDUCED ANALGESIA IN MICE
- The Opioid Activity and Receptor Selectivity of Fluorinated Leu^5 Enkephalin Analogues in Vitro and in Vivo
- The Opioid Receptor Selectivity for Trimebutine in Isolated Tissues Experiments and Receptor Binding Studies
- Selectivity for Opioid Receptor Subtypes of Enkephalin Analogues in Isolated Smooth Muscle and in the Analgesic Effect in Mice
- Distinctive Effect of Ginseng Saponins on Development of Morphine Tolerance in Guinea-Pig Ileum and Mouse vas Deferens
- INVOLVEMENT OF DIFFERENT RECEPTOR SUBTYPES FOR THE PRODUCTION OF IN VITRO AND IN VIVO EFFECTS IN A SERIES OF SYNTHETIC ENKEPHALIN ANALOGUES
- Role of GABAergic Systems in the Development of Morphine Tolerance in Formalin-Treated Mice
- Effects of Footshock-, Psychological- and Forced Swimming-Stress on the Leaning and Memory Processes: Involvement of Opioidergic Pathways
- Comparative Studies on the Inhibitory Effect of Morphine, Pentobarbital and Ethanol on the Electrically Evoked Contractions of Isolated Mouse Vas Deferens
- A SCORING SYSTEM FOR ABSTINENCE SYNDROME IN MORPHINE DEPENDENT MICE AND APPLICATION TO EVALUATE MORPHINE TYPE DEPENDENCE LIABILITY OF DRUGS
- STUDIES ON PHYSICAL DEPENDENCE INDUCIBLE BY HOURS EXPOSURE OF MICE TO MORPHINE
- Implication of ATP-Sensitive K^+ Channels in Various Stress-Induced Analgesia (SIA) in Mice
- THE MORPHINE 3-GLUCURONIDE DIRECTED ANTIBODY: ITS IMMUNOLOGICAL SPECIFICITY AND POSSIBLE USE FOR RADIOIMMUNOASSAY OF MORPHINE IN URINE
- DEVELOPMENT OF PHYSICAL DEPENDENCE ON MORPHINE NOT ACCOMPANIED WITH TOLERANCE FORMATION
- A SIMPLE QUANTITATIVE METHOD FOR THE EVALUATION OF PHYSICAL DEPENDENCE LIABILITY OF MORPHINE IN MICE
- CROSS REVERSE TOLERANCE BETWEEN AMPHETAMINE, COCAINE AND MORPHINE
- Synaptic Plasticity: Stairway to Memory
- FURTHER STUDIES ON THE DETERMINANT ROLE OF BRAIN LEVEL OF PENTOBARBITAL FOR THE DEVELOPMENT OF ACUTE HYPNOTIC TOLERANCE
- DRUG METABOLIZING FUNCTION OF ISOLATED PERFUSED LIVER
- RADIOIMMUNOASSAY OF METHIONINE ENKEPHALIN AND INTERFERENCE BY BRAIN FACTOR OF IMMUNOREACTIVITY AND OPIATE RECEPTOR BINDING ACTIVITY
- URINARY EXCRETION PATTERNS OF MORPHINE IN HUMANS FOLLOWED BY AN RADIOIMMUNOASSAY METHOD
- PROTEIN SYNTHESIS IN MOUSE BRAIN DURING DEVELOPMENT OF ACUTE MORPHINE TOLERANCE
- ANTIBODIES TO BSA CONJUGATES OF MORPHINE DERIVATIVES: STRICT DEPENDENCY OF THE IMMUNOLOGICAL SPECIFICITY ON THE HAPTEN STRUCTURE
- MORPHINE SPECIFIC SEIZURE INDUCED IN POLY-D-LYSINE PRETREATED MICE AND SOME EVIDENCE SUGGESTING THE PRESENCE OF A NOVEL SITE FOR THE MORPHINE EFFECT
- PARTICIPATION OF LIVER FUNCTION IN THE ACUTE TOLERANCE TO PENTOBARBITAL INDUCED AFTER SHORT-TERM INFUSION
- Distinctive implication of emotional factors in various types of stress-induced analgesia.
- Diversity of underlying mechanisms in the production of analgesic and pentobarbital-hypnosis prolonging effects of various analgesic drugs and stresses.
- Comparative studies on morphine- and stress-induced analgesia and the development of tolerance to the effects: Implication of protein synthesis mechanism in the process.
- Morphine analgesia without development of tolerance in reserpinized mice.
- Important role of adrenergic function in the development of analgesic tolerance to morphine in mice.
- Facilitation of memory retrieval by pre-test morphine and its state dependency in the step-through type passive avoidance learning test in mice.
- Reverse tolerance to the swimming time prolonging effect of d-amphetamine in mice.
- Differential Roles of the Adrenal Gland in the Suppression of Morphine Antinociceptive Tolerance Development by .ALPHA.- and .BETA.-Adrenergic Blockers.
- Development of Tolerance to Morphine Antinociception in Mice Treated with Nociceptive Stimulants.
- Adrenergic function and the development of analgesic tolerance to morphine.
- Blockade by Ginseng Extract of the Development of Reverse Tolerance to the Ambulation-Accelerating Effect of Methamphetamine in Mice.
- Single dose tolerance to the analgesic effect of clonidine and cross-tolerance between morphine and clonidine.
- The role of the catecholaminergic mechanism in foot shock (FS) stress- and immobilized-water immersion (IW) stress-induced analgesia in mice.
- Further evidence for the implication of a .KAPPA.-opioid receptor mechanism in the production of psychological stress-induced analgesia.
- Role of adrenal glucocorticoids in the blockade of the development of analgesic tolerance to morphine by footshock stress exposure in mice.
- Involvement of Pain Associated Anxiety in the Development of Morphine Tolerance in Formalin Treated Mice.
- Anti-Stress Effect of Ginseng on the Inhibition of the Development of Morphine Tolerance in Stressed Mice.
- Blockade of the development of analgesic tolerance to morphine by concurrent treatment with opioid-but not non-opioid-mediated stress in mice.
- Dual action mechanisms of KK-3, a newly synthesized leu-enkephalin derivative, in the production of spinal analgesic effects.
- Blockade of the development of analgesic tolerance to morphine by psychological stress through benzodiazepine receptor mediated mechanism.
- Footshock- and Psychological-Stress Prevent the Development of Tolerance to Spinal but Not Supraspinal Morpine.
- Involvement of Serotonergic Receptor Subtypes in the Production of Antinociception by Psychological Stress in Mice.
- Morphine Dependence With or Without Tolerance in Formalin-Treated Mice: Further Evidence for the Dissociation.