Implication of ATP-Sensitive K^+ Channels in Various Stress-Induced Analgesia (SIA) in Mice
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概要
- 論文の詳細を見る
Exposure to footshock (2 mA, 1-sec duration, 0.2 Hz for 15 min; FS), forced swimming (water at 20°C for 3 min, SW) or psychological stress (using a communication box for 5 min, PSY) produced antinociceptive effects (stress-induced analgesia, S1A). Intracerebroventricular (i.c.v.) injection of glibenclamide (10-40 μg/mouse), an ATP-sensitive K<SUP>+</SUP> (K<SUB>ATP</SUB>) channel blocker, antagonized FS-SIA, while SW- and PSY-SIA were unaffected by the compound. Cromakalim (0.1-10 μg/mouse, i.c.v.), a K<SUB>ATP</SUB>-channel opener, did not affect FS-, SW- or PSY-SIA. Thus, we provided evidence that central K<SUB>ATP</SUB> channels participate in the production of FS-SIA but not production of SW or PSY-SIA; and we suggest that glibenclamide, through closing of K<SUB>ATP</SUB> channels, suppresses μ-opioid receptor functions, which subsequently leads to the inhibition of FS-SIA since antinociception is produced by the activation of μ-receptors.
- 社団法人 日本薬理学会の論文
著者
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KANETO Hiroshi
Emeritus Professor, Nagasaki University
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Takahashi M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Takahashi Masakatsu
Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University
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Kaneto Hiroshi
Emeritus Professor Nagasaki University
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
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NAKAO Kaoru
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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Takahashi Masakatsu
Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University
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