A Potent Mu-Opioid Receptor Agonist, Dihydroetorphine, Fails to Produce the Conditioned Place Preference in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Reinforcing effects of dihydroetorphine (DHE) and morphine were evaluated by the conditioned place preference paradigm. Both DHE and morphine produced an antinociceptive effect in a dose-dependent manner. On the other hand, DHE (0.1, 1, 3 and 10 μg/kg, i.p.) failed to induce the conditioned preference, while morphine (0.1, 1, 3 and 10 mg/kg, i.p.) caused a dose-dependent preference for the drug-paired place. Thus, these characteristic properties of DHE make it attractive for development as a novel potent analgesic compound that has less dependence liability.
- 社団法人 日本薬理学会の論文
- 1996-08-01
著者
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Tokuyama Shogo
Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences
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Tokuyama S
長崎大学 薬 分子薬理
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Tokuyama Shogo
Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences
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KANETO Hiroshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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TAKAHASHI Masakatsu
Department of Respiratory Medicine, Kanazawa Medical University
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NAKAMURA Fumihiro
Department of Psychiatry, Shizuoka Institute of Epilepsy and Neurological Disorders
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KANETO Hiroshi
Emeritus Professor, Nagasaki University
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Takahashi M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Takahashi Masakatsu
Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University
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Kaneto H
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
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Nakamura F
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Nakamura Fumihiro
Department Of Psychiatry Shizuoka Institute Of Epilepsy And Neurological Disorders
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NAKAO Kaoru
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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NAKAMURA Fumihiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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Takahashi Masakatsu
Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University
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