Preventive Effect of Morinda citrifolia Fruit Juice on Neuronal Damage Induced by Focal Ischemia(Pharmacognosy)
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概要
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It is known that the fruit juice of Morinda citrifolia (M. citrifolia, Noni, Rubiaceae) has various pharmacological effects such as antioxidant or anti-inflammatory activities, which may help the inhibition of ischemic neuronal damage. Here, we examined the effect of the fruit juice of M. citrifolia (Noni juice) on the brain damage caused by ischemic stress in mice. Noni juice was obtained from the mature fruit grown in Okinawa (about 1.5l/4kg of fruit; 100% Okinawa Noni juice (ONJ). Male ddY mice were supplied with 3% or 10% juice in the drinking water for 7d, and compared to the control group. On the 7th day, mice were subjected to 2h of middle cerebral artery occlusion (MCAO). Interestingly, the intake of juice reduced the infarct volume as analyzed by 2,3,5-triphenyltetrazolium chloride (TTC) staining on the 3rd day of MCAO when compared to the control group. Furthermore, we found that the neurological deficit scores (NDS) were decreased after the reperfusion in the juice-supplied mice. On the other hand, the intake of juice did not affect the expression levels of antioxidant such as Cu/Zn superoxide dismutase. The present study suggests that Noni juice may have a preventive effect against cerebral ischemic stress, while further studies are needed to explain the detailed mechanism.
- 2009-03-01
著者
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YAMAMOTO Junichiro
Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University
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Tokuyama Shogo
Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences
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Kamiya Kohei
Department of Pharmacognosy and Natural Product Chemistry, School of Pharmaceutical Sciences, Kobe G
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Satake Toshiko
Department of Pharmacognosy and Natural Product Chemistry, School of Pharmaceutical Sciences, Kobe G
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Harada Shinichi
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Japan
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Kamiya Kohei
Dep. Of Pharmacognosy And Natural Product Chemistry Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ
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Kamiya Kohei
Department Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences Kobe Ga
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Satake T
Faculty Of Pharmaceutical Sciences Kobe Gakuin University:high Technology Research Center Kobe Gakui
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Satake Toshiko
Department Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences Kobe Ga
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Tokuyama Shogo
Dep. Of Clinical Pharmacy Kobe Gakuin Univ. School Of Pharmaceutical Sciences
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Tokuyama Shogo
Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences
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HAMABE Wakako
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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Hamabe Wakako
Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Harada Sachiko
Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kamiya Kohei
Dep. Of Pharmacognosy And Natural Product Chemistry School Of Pharmaceutical Sciences Kobe Gakuin Un
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Yamamoto Junichiro
Laboratory Of Physiology Faculty Of Nutrition Kobe Gakuin University
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Satake Toshiko
Dep. Of Pharmacognosy And Natural Product Chemistry School Of Pharmaceutical Sciences Kobe Gakuin Un
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Harada Shinichi
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
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