Chemical Constituents of Morinda citrifolia Roots Exhibit Hypoglycemic Effects in Streptozotocin-Induced Diabetic Mice(Pharmacognosy)

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概要

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• The hypoglycemic effects of the chemical constituents of Morinda citrifolia roots was evaluated in streptozotocin (STZ)-induced diabetic mice. The CHCl_3, EtOAc, n-BuOH and H_2O soluble phases of the MeOH extract of M. citrifolia roots were administrated orally to STZ-induced diabetic mice. Only the n-BuOH soluble phase showed a significant reduction of the blood glucose levels. From the biologically active n-BuOH soluble phase, two iridoids and three anthraquinones were isolated as main constituents. These compounds were identified by spectroscopic analysis to be deacetylasperulosidic acid (1), asperulosidic acid (2), damnacanthol-3-0-β-D-primeveroside (3), lucidin 3-0-β3-D-primeveroside (4) and morindone-6-O-β-D-primeveroside (5). 3 and 4 exhibited the hypoglycemic effects, which were anthraquinones with no substituents in one aromatic ring.

• 公益社団法人日本薬学会の論文
• 2008-05-01

著者

• Kamiya Kohei

  Dep. Of Pharmacognosy And Natural Product Chemistry Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ

• Kamiya Kohei

  Department Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences Kobe Ga

• Kamiya Kohei

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Satake T

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University:high Technology Research Center Kobe Gakui

• Satake Toshiko

  Department Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences Kobe Ga

• Satake Toshiko

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tokuyama Shogo

  Dep. Of Clinical Pharmacy Kobe Gakuin Univ. School Of Pharmaceutical Sciences

• Hamabe Wakako

  Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Harada Sachiko

  Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• HAMABE Wakako

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• HARADA Sachiko

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• MURAKAMI Rie

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• TOKUYAMA Shogo

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Kamiya Kohei

  Dep. Of Pharmacognosy And Natural Product Chemistry School Of Pharmaceutical Sciences Kobe Gakuin Un

• Murakami Rie

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Satake Toshiko

  Dep. Of Pharmacognosy And Natural Product Chemistry School Of Pharmaceutical Sciences Kobe Gakuin Un

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