The Anti-thrombotic Active Constituents from Centella asiatica(Pharmacognosy)
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概要
- 論文の詳細を見る
The in vitro effects of a methanol extract from the aerial parts of Centella asiatica on shear-induced platelet activation and coagulation were assessed after oral administration to rats, by subjecting non-anticoagulated blood to haemostatometry. 3,5-Di-O-caffeoyl quinic acid, 1,5-di-O-caffeoyl quinic acid, 3,4-di-O-caffeoyl quinic acid, 4,5-di-O-caffeoyl quinic acid, and chlorogenic acid, together with asiaticoside, kaempferol, quercetine, kaempferol-3-O-β-D-glucoside and quercetin-3-O-β-D-glucoside were all isolated from the methanol extract. Amongst these, only 3,5-di-O-caffeoylquinic acid showed significant inhibition of shear-induced platelet activation and dynamic coagulation. The reactive curve of the inhibitory effect on the platelet reaction and the dynamic coagulation showed a bell-shape.
- 公益社団法人日本薬学会の論文
- 2007-05-01
著者
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Kamiya Kohei
Dep. Of Pharmacognosy And Natural Product Chemistry Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ
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Kamiya Kohei
Department Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences Kobe Ga
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Kamiya Kohei
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Satake T
Faculty Of Pharmaceutical Sciences Kobe Gakuin University:high Technology Research Center Kobe Gakui
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Satake Toshiko
Department Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences Kobe Ga
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Satake Toshiko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kamiya Kohei
Dep. Of Pharmacognosy And Natural Product Chemistry School Of Pharmaceutical Sciences Kobe Gakuin Un
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AN Yin
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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OISHI Tomomi
Facuty of Nutrition, Kobe Gakuin University
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YAMAMOTO Junichiro
Facuty of Nutrition, Kobe Gakuin University
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Satake Toshiko
Dep. Of Pharmacognosy And Natural Product Chemistry School Of Pharmaceutical Sciences Kobe Gakuin Un
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Oishi Tomomi
Facuty Of Nutrition Kobe Gakuin University
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An Yin
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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