Dynamic Structures of Granulocyte Colony-Stimulating Factor Proteins Studied by Normal Mode Analysis : Two Domain-Type Motions in Low Frequency Modes

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概要

• 論文の詳細を見る

• In this study, granulocyte colony-stimulating factor (GCSF) proteins were chosen as subjects for normal mode analysis. As helical cytokines with a four helix bundled type topology, they were classified into long chain and short chain groups by Sprang and Bazan. Normal mode calculations were also carried out with leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and growth hormone (GH) as members of the long chain group and GCSF and IL-2 and IL-4 as members of the short chain group. For the GCSF families it was found that the fluctuations in the helical region are smaller than in the loop region, and it is clear that on the whole the smaller fluctuation residues belong to a large hydrophobic core region. Thus, it can be imagined how the receptor binding sites approach the receptor within the normal time-scale of pico seconds. In addition, two similar domain-type motions in low frequency modes were found with proteins in the chain group, although we never observed any sequence similarity in the two separate two-domain regions in each protein of the long chain group. On the other hand, these two domain-type motions were not clear in proteins of the short chain group.

• 社団法人日本薬学会の論文
• 1998-07-15

著者

• Umeyama Hideaki

  School of Pharmacy, Kitasato University

• Nakajima Yukiko

  Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo

• KAMIYA Kenshu

  School of Science, Kitasato University

• SUMIKAWA Hiromi

  Central Research Laboratories, Ajinomoto Co., Inc.

• Kamiya Kohei

  Dep. Of Pharmacognosy And Natural Product Chemistry Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ

• Kamiya Kohei

  Department Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences Kobe Ga

• Nakajima Y

  Ohta's Isan Co. Ltd. Ibaraki Jpn

• Nakajima Yasushi

  Nissan Research Center Nissan Motor Co. Ltd.

• SUZUKI Ei-ichiro

  Central Research Laboratories, Ajinomoto Co., Inc.

• FUKUHARA Ken-ichi

  Central Research Laboratories, Ajinomoto Co., Inc.

• NAKAJIMA Yasushi

  School of Pharmaceutical Sciences, Kitasato University

• Kamiya Kohei

  Dep. Of Pharmacognosy And Natural Product Chemistry School Of Pharmaceutical Sciences Kobe Gakuin Un

• Sumikawa H

  Central Research Laboratories Ajinomoto Co. Inc.

• Sumikawa Hiromi

  Central Research Laboratories Ajinomoto Co. Inc.

• Kamiya Kenshu

  School Of Science Kitasato University

• Umeyama Hideaki

  Dep. Of Biomolecular Design School Of Pharmaceutical Sciences Kitasato Univ.

• Umeyama Hideaki

  School Of Pharmaceutical Sciences Kitasato University

• Suzuki E

  Hoechst Marion Roussel Ltd. Kawagoe Jpn

• Suzuki Ei-ichiro

  Central Research Laboratories Ajinomoto Co. Inc.

• Suzuki Ei-ichiro

  Institute Of Life Sciences Ajinomoto Co Inc

• Fukuhara K

  Central Research Laboratories Ajinomoto Co. Inc.

• Fukuhara Ken-ichi

  Central Research Laboratories Ajinomoto Co.

• 鈴木 恵理香

  Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University

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