Tertiary Structural Models of Human Interleukin-6 and Evaluation by Comparison with X-Ray and NMR Structures

スポンサーリンク

概要

• 論文の詳細を見る

• Tertiary structure models of interleukin-6 were construted using a routine prediction method based on the X-ray crystal structures of granulocyte colony-stimulating factor (GCSF) and leukemia inhibitory factor (LIF). Those models were evaluated using a sequence-structure compatibility (3D-1D) method program Compass and a limited amount of NMR distance information when it was concluded that the model based on GCSF (IBGC) was preferable to that from LIF (Sumikawa et al., FEBS Lett., 404,234 (1997)). We evaluated the quality of this model (IBGC) by comparing with X-ray (Somers et al., EMBO. J., 16,989 (1997)) and NMR (Xu et al., J. Mol. Biol., 268,468 (1997)) structures. Consequently, normal mode calculations were carried out for this model, giving conformation fluctuations similar to the C alpha deviation pattern between X-ray and NMR structures.

• 公益社団法人日本薬学会の論文
• 1998-01-15

著者

• SUMIKAWA Hiromi

  Central Research Laboratories, Ajinomoto Co., Inc.

• Suzuki E

  Central Research Laboratories Ajinomoto Co. Inc.

• Sumikawa Hiromi

  Central Research Laboratories Ajinomoto Co. Inc.

• Suzuki Ei-ichiro

  Central Research Laboratories Ajinomoto Co. Inc.

関連論文

• Dynamic Character of Human Growth Hormone and Its Receptor: Normal Mode Analysis
• Dynamic Structures of Granulocyte Colony-Stimulating Factor Proteins Studied by Normal Mode Analysis : Two Domain-Type Motions in Low Frequency Modes
• Crystal Structure of N-(4-Methyl-5-oxo-1-imidazolin-2-yl)sarcosine Monohydrate
• Intermediate State during the Crystal Transition in Aspartame, Studied with Thermal Analysis, Solid-State NMR, and Molecular Dynamics Simulaiton
• Tertiary Structural Models of Human Interleukin-6 and Evaluation by Comparison with X-Ray and NMR Structures
• NMR study on inclusion complexes of L-phenylalanine and aspartame with cyclodextrins in aqueous solution.
• State of Water in Maillard-reacted Ovalbumin as Studied by Broad-line Pulsed NMR
• The number of water molecules bound to insulin.

スポンサーリンク