Comparative Pharmacodynamics of Eight Calcium Channel Blocking Agents in Japanese Essential Hypertensive Patients
スポンサーリンク
概要
- 論文の詳細を見る
The relationships between plasma drug concentration and antihypertensive effect of eight calcium channel antagonists (nicardipine, nifedipine, nilvadipine, benidipine, manidipine, barnidipine, nitrendipine and efonidipine) in Japanese essential hypertensive patients were analyzed. Based on the effect compartment model, we could explain the long duration of the pharmacological effect, and there was significant correlation (r=0.876,p<0.05) between estimated EC_<50> values and the dissociation constants (K_d) obtained from in vitro binding studies. We also developed the ion-channel binding model to understand the pharmacodynamics of long acting calcium antagonists. The model was also well fitted to antihypertensive effect data. A significant correlation between the apparent in vivo dissociation constants and in vitro K_d values was observed with a slope of 1.45 (r=0.913), suggesting that the mechanism of long-lasting antihypertensive effect of newer developed calcium antagonists is due to their high binding affinity at ion-channel sites.
- 公益社団法人日本薬学会の論文
- 1996-03-15
著者
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Nakajima Yukiko
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
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YAMAMOTO Koujirou
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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SAWADA Yasufumi
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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IGA Tatsuji
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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Shimada S
Univ. Tokyo Tokyo
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Shimada Shuji
東京大学医学部附属病院 薬剤
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Shimada Shuji
Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and
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Sawada Yasufumi
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine University Of Tokyo
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Nakajima Yukiko
Department Of Pharmaceutics Kyoritsu College Of Pharmacy
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Yamamoto Koujirou
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
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Yamamoto Koujirou
Department Of Pharmacy The Gunma University Hospital Gunma University School Of Medicine:department
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Yamamoto Koujirou
Department Of Clinical Pharmacology Gunma University School Of Medicine
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Yamamoto Koujirou
Department Of Clinical Pharmacology Gunma University Graduate School Of Medicine
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Iga T
Department Of Pharmacy University Of Tokyo Hospital
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Iga Tatsuji
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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Shimada Shuji
Department Of Clinical Pharmacology Graduate School Of Pharmaceutical Sciences Toyama Medical And Ph
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Nakada Y
Nippon Organon K. K. Osaka Jpn
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Yamano Katsuhiro
Biopharmaceutical And Pharmacokinetic Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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