Determination of Isepamicin in Human Plasma by HPLC with Fluorescence Detection after Derivatization Using 6-Aminoquinolyl-N-hydroxysuccinimidyl-carbamate(Analytical Biochemistry)
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概要
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A simple and rapid high-performance liquid chromatographic method has been developed for determination in human plasma of isepamicin (ISP), an aminoglycoside antibiotic agent. After protein precipitation and clean-up procedure to remove lipophilic contaminants, ISP is derivatized pre-column with 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate for fluorescence detection. Chromatographic separations are achieved using C_<18> column and mobile phase consisting of 20mM KH_2PO_4 containing 8mM triethylamine (pH 7.0) and acetonitrile (78/22, v/v). Amikacin was used as an internal standard. The calibration curve was linear over a concentration range of 0.5-50μg/ml. The limit of quantification was 0.5μg/ml. The intra-and inter-day variabilities of ISP were both less than 17.5%. Both derivatives were stable for at least a week at ambient condition. This assay procedure should have useful application in therapeutic drug monitoring of ISP.
- 公益社団法人日本薬学会の論文
- 2008-10-01
著者
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YAMAMOTO Koujirou
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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HORIUCHI RYUYA
Department of Clinical Pharmacology, Gunma University Graduate School of Medicine
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Horiuchi Ryuya
Department Of Pharmacy The Gunma University Hospital Gunma University School Of Medicine:department
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Yamamoto Keiko
Department Of Pharmaceutics
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NAKAMURA Katsunori
Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University
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Nakayama K
Laboratory Of Drug Metabolism Graduate School Of Pharmaceutical Sciences Hokkaido University
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Horiuchi Ryuya
Department Of Clinical Pharmacology Gunma University Graduate School Of Medicine
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Yamamoto Koujirou
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
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Yamamoto Koujirou
Department Of Pharmacy The Gunma University Hospital Gunma University School Of Medicine:department
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Yamamoto Koujirou
Department Of Clinical Pharmacology Gunma University School Of Medicine
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Yamamoto Koujirou
Department Of Clinical Pharmacology Gunma University Graduate School Of Medicine
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Nakayama Kazuo
Laboratory Of Drug Metabolism Division Of Pharmacobio-dynamics Graduate School Of Pharmaceutical Sci
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HOSOKAWA Shin
Department of Pharmacy, The Gunma University Hospital, Gunma University School of Medicine
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FUJITA Yukiyoshi
Department of Pharmacy, The Gunma University Hospital, Gunma University School of Medicine
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Nakayama Katsuo
Department Of Clinical Pharmacology Graduate School Of Medicine Gunma University
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Horiuchi Ryuya
Department Of Clinical Pharmacology And Department Of Pharmacy Gunma University School Of Medicine
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Nakamura Katsunori
Department Of Clinical Pharmacology Graduate School Of Medicine Gunma University
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Hosokawa Shin
Department Of Pharmacy The Gunma University Hospital Gunma University School Of Medicine
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Fujita Yukiyoshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences University Of Shizuoka
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Fujita Yukiyoshi
Department Of Pharmacy The Gunma University Hospital Gunma University School Of Medicine
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Yamano Katsuhiro
Biopharmaceutical And Pharmacokinetic Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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