INHIBITION OF GABA_A RECEPTOR-MEDIATED CURRENT RESPONSES BY ENOXACIN (NEW QUINOLONE) AND FELBINAC (NON-STEROIDAL ANTI-INFLAMMATORY DRUG) IN XENOPUS OOCYTES INJECTED WITH MOUSE-BRAIN MESSENGER RNA
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概要
- 論文の詳細を見る
The convulsant interaction between enoxacin (ENX), a new quinolone antibacterial agent (NQ), and felbinac (FLB), a non-steroidal anti-inflammatory drug (NSAID), in vivo was reproduced as the change of GABA-induced current response in Xenopus oocytes injected with mouse brain mRNA. GABA (10 μM) response was inhibited by ENX in a dose-dependent manner, and IC_<50> of ENX was 96 μM. Moreover, the inhibitory effect of ENX was 80-fold potentiated in the presence of 10 μM FLB. The GABA_A-antagonistic interaction between these two drugs in vitro was considered a possible mechanism of convulsant reaction after concomitant administration of NQs and NSAIDs in vivo.
- 社団法人日本薬学会の論文
- 1993-07-15
著者
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伊賀 立二
Departments of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of To
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伊賀 立二
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine University Of Tokyo
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KAWAKAMI Junichi
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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SHIMOKAWA Masafumi
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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YAMAMOTO Koujirou
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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SAWADA Yasufumi
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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浅沼 厚
Department of Physiology, School of Dental Medicine, Tsurumi University
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柳沢 慧二
Department of Physiology, School of Dental Medicine, Tsurumi University
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柳沢 慧二
鶴見大学歯学部生理学教室
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柳沢 慧二
鶴見大学歯学部口腔生理学
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柳沢 慧二
鶴見大・歯・生理
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Sawada Y
Univ. Tokyo Tokyo Jpn
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Sawada Yasufumi
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine University Of Tokyo
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浅沼 厚
鶴見大学歯学部生理学教室
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Yamamoto Koujirou
Department Of Clinical Pharmacology Gunma University Graduate School Of Medicine
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Yamamoto Koujirou
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine University Of Tokyo
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Kawakami Junichi
Department Of Hospital Pharmacy Hamamatsu University School Of Medicine
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Kawakami Junichi
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine University Of Tokyo
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Shimokawa Masafumi
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine University Of Tokyo
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