Pharmacokinetic Variability of Mycophenolic Acid and Its Glucuronide in Systemic Lupus Erythematosus Patients in Remission Maintenance Phase
スポンサーリンク
概要
- 論文の詳細を見る
The aim of this study was to identify factors affecting the pharmacokinetics of mycophenolic acid (MPA) and its 7-O-glucuronide (MPAG) in systemic lupus erythematosus (SLE) patients. Thirty-one SLE patients in remission maintenance phase treated with mycophenolate mofetil (median 1500 mg/d) and prednisolone and followed-up for up to 56 months (median 13 months) were enrolled. Creatinine clearance and metal medication were significant predictors accounting for interindividual variability in the dose-normalized predose plasma concentration (C0) of MPA (adjusted R2=0.305, p=0.01) in a multivariate analysis. Dose-normalized MPAG C0 was significantly correlated with only creatinine clearance (adjusted R2=0.135, p=0.03). The free fraction of MPA was significantly correlated with only serum albumin (adjusted R2=0.700, p<0.01). The free fraction of MPAG was significantly correlated with serum albumin, metal medication, and age (adjusted R2=0.598, p=0.02). In conclusion, renal function and co-administered metal influenced the pharmacokinetics of MPA and MPAG in SLE patients in remission maintenance phase.
著者
-
KAWAKAMI Junichi
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
-
NAITO Takafumi
Department of Clinical Pharmacy, Oita Medical University
-
Naito T
浜松医科大学 医学部附属病院薬剤部
-
Naito Takafumi
Department Of Hospital Pharmacy Hamamatsu University School Of Medicine
-
MINO Yasuaki
Department of Hospital Pharmacy, Hamamatsu University School of Medicine
-
SHIMOYAMA Kumiko
Third Department of Internal Medicine, Hamamatsu University School of Medicine
-
OGAWA Noriyoshi
Third Department of Internal Medicine, Hamamatsu University School of Medicine
-
Ogawa Noriyoshi
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
-
Kawakami Junichi
Department Of Hospital Pharmacy Hamamatsu University School Of Medicine
-
Shimoyama Kumiko
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
関連論文
- INHIBITION OF GABA_A RECEPTOR-MEDIATED CURRENT RESPONSES BY ENOXACIN (NEW QUINOLONE) AND FELBINAC (NON-STEROIDAL ANTI-INFLAMMATORY DRUG) IN XENOPUS OOCYTES INJECTED WITH MOUSE-BRAIN MESSENGER RNA
- Inhibitory Effect of Azole Antifungal Agents on the Glucuronidation of Lorazepam Using Rabbit Liver Microsomes in Vitro
- Some Gastrointestinal Function Regulatory Kampo Medicines Have Modulatory Effects on Human Plasma Adrenocorticotropic Hormone and Cortisol Levels with Continual Stress Exposure(Pharmacology)
- Influence of Metal Cations on Plasma Trough Concentration of Mycophenolic Acid and Its Glucuronide in Tacrolimus-Treated and Cyclosporine-Treated Kidney Transplant Recipients(Biopharmacy)
- Effects of Calcineurin Inhibitors on Pharmacokinetics of Mycophenolic Acid and Its Glucuronide Metabolite during the Maintenance Period Following Renal Transplantation(Pharmacology)
- Limb-saving surgery in osteosarcoma by vascularized fibular graft
- Effect of Renal Failure on Neurotoxicity of Ranitidine in Rats
- Monitoring Plasma Neuropeptide-Like Immunoreactivity Levels in a Patient Given Hange-koboku-to for a Week for Swallowing Reflex Disorder
- A case of proteinase 3-antineutrophil cytoplasmic antibody-positive Sjogren's syndrome complicated with interstitial nephritis
- CD40-CD40 ligand signal induces the intercellular adhesion molecule-1 expression through nuclear factor-kappa B p50 in cultured salivary gland epithelial cells from patients with Sjogren's syndrome
- Changes in Electrophysiological Properties of Rat Skin with Age
- Age Dependency of Esterase Activity in Rat and Human Keratinocytes(Biopharmacy)
- Age Difference in Simultaneous Permeation and Metabolism of Ethyl Nicotinate in Rat Skin
- Onset of Clinical Effects and Plasma Concentration of Fluvoxamine in Japanese Patients
- Effects of Cigarette Smoking and Cytochrome P450 2D6 Genotype on Fluvoxamine Concentration in Plasma of Japanese Patients
- Neurotoxic Convulsions Induced by Theophylline and Its Metabolites in Mice
- Pharmacokinetic Variability of Mycophenolic Acid and Its Glucuronide in Systemic Lupus Erythematosus Patients in Remission Maintenance Phase
- Nicotinic Enhancement of Proliferation in Bovine and Porcine Cerebral Microvascular Endothelial Cells(Pharmacology)
- Enzyme Immunoassay of Adrenocorticotropic Hormone-like Immunoreactive Substance in Human Plasma
- Enzyme Immunoassay for Secretin-like Immunoreactive Substance in Human Plasma
- Effect of Oral Administration of Dai-ken-chu-to on Brain-gut Peptides Concentrations in Plasma of Healthy Subjects
- Significant Change of Gastrointestinal Peptides Levels in Plasma after Administration of Histamine H_2-receptor Antagonists
- Enzyme Immunoassay of Calcitonin Gene-Related Peptide-like Immunoreactive Substance in Human Plasma and Saliva
- A Case whose Gastric Function was Estimated Based on the Plasma Levels of Acetaminophen and Gastrointestinal Peptides
- Determination of Granisetron in Human Plasma by High-performance Liquid Chromatography
- Significant Change of VIP Levels in Plasma after Administration of Elcatonin
- Unique gene expression pattern of peripheral blood in patients with Sjogren's syndrome
- Inhibition of Theophylline Metabolism by Suplatast and Its Metabolites in Rats(Biopharmacy)
- Application of an Enzyme Immunoassay for Nociceptin (Orphanin FQ)-like Immunoreactive Substances to Determination of the Human Plasma Levels
- Permeation Enhancement of Ketoprofen Using a Supersaturated System with Antinucleant Polymers(Biopharmacy)
- Neurotoxic Study of H_2 Antagonists Using Xenopus Oocytes Injected with Mouse-Brain mRNA
- Effect of Acute Renal Failure on Neurotoxicity of Enoxacin in Rats
- Lack of Potentiation with Felbinac Patch on the Convulsive Toxicity of Enoxacin in Rats
- Effects of Hange-koboku-to (Banxia-houpo-tang) on Neuropeptide Levels in Human Plasma and Saliva(Pharmacology)
- Comparison of the Effects of Hange-shashin-to and Rikkunshi-to on Human Plasma Calcitonin Gene-Related Peptide and Substance P Levels(Pharmacology)
- Lafutidine Changes Levels of Somatostatin, Calcitonin Gene-Related Peptide, and Secretin in Human Plasma
- Hange-shashin-to Raises Levels of Somatostatin, Motilin, and Gastrin in the Plasma of Healthy Subjects
- Effects of Mosapride Citrate on Human Plasma Levels of Motilin, Gastrin, Somatostatin, and Secretin
- Rikkunshi-to Raises Levels of Somatostatin and Gastrin in Human Plasma
- Effects of Ninjin-to on Levels of Brain-Gut Peptides (Motilin, Vasoactive Intestinal Peptide, Gastrin, and Somatostatin) in Human Plasma
- Effects of Dai-kenchu-to on Levels of 5-Hydroxytryptamine (Serotonin) and Vasoactive Intestinal Peptides in Human Plasma
- Effect of Dai-kenchu-to on Levels of 3 Brain-gut Peptides (Motilin, Gastrin and Somatostatin) in Human Plasma
- Simple and Rapid HPLC-UV Method Using an Ultrafine Particle Octadecylsilane for Determination of Residual Fentanyl in Applied Durotep MT Transdermal Matrix Patches and Its Clinical Application
- Comparison of Contamination Levels on the Exterior Surfaces of Vials Containing Platinum Anticancer Drugs in Japan
- Interindividual Variations in Aprepitant Plasma Pharmacokinetics in Cancer Patients Receiving Cisplatin-Based Chemotherapy for the First Time
- Effect of Aging and Gender on Internal Anal Sphincter Thickness