Influence of Metal Cations on Plasma Trough Concentration of Mycophenolic Acid and Its Glucuronide in Tacrolimus-Treated and Cyclosporine-Treated Kidney Transplant Recipients(Biopharmacy)
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概要
- 論文の詳細を見る
The aim of this study was to evaluate the plasma trough concentrations (C_0) of mycophenolic acid (MPA) and its major metabolite MPA 7-O-glucuronide (MPAG) in metal cation (MC)(-) (non-treated) and MC(+) (co-treated) patients who received tacrolimus (Tac) or cyclosporine (CyA). Fifty-nine Japanese stable kidney transplant recipients receiving immunosuppressive regimens containing mycophenolate mofetil (MMF) and a calcineurin inhibitor (CNI) were included in this study. Seven in the 25 patients receiving Tac and 8 in the 34 patients receiving CyA were treated with concomitant MCs administration. Multiple regression analysis revealed that concomitant MCs and CyA administration influenced MPA C_0. Their standardized partial regression coefficients were -0.29 and -0.41, respectively. Stratified analysis based on CNI treatment revealed that MPA C_0 decreased significantly by 56% with concomitant MCs administration in Tac-treated patients. There was no significant difference in MPA C_0 between the MC(-) and MC(+) groups in CyA-treated patients. With respect to MPAG C_0, MC(+) group tended to be lower by 26% than MC(-) group in Tac-treated patients. There was no significant difference in MPAG C_0 between the MC(-) and MC(+) groups in CyA-treated patients. Concomitant MCs administration did not affect the C_0 ratio of MPAG to MPA in either Tac- or CyA-treated patients. In conclusion, MCs co-administration decrease MPA C_0 in patients receiving Tac and may cause lower MPA exposure. There are little pharmacokinetic interactions between MMF and concomitant MCs in CyA-treated patients.
- 公益社団法人日本薬学会の論文
- 2008-06-01
著者
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KAGAWA Yoshiyuki
Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University
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KAWAKAMI Junichi
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo
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Ushiyama Tomomi
Department Of Surgery Kikugawa General Hospital
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OZONO Seiichiro
Department of Urology, Nara Medical University
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NAITO Takafumi
Department of Clinical Pharmacy, Oita Medical University
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Naito T
浜松医科大学 医学部附属病院薬剤部
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Naito Takafumi
Department Of Hospital Pharmacy Hamamatsu University School Of Medicine
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MINO Yasuaki
Department of Hospital Pharmacy, Hamamatsu University School of Medicine
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OTSUKA Atsushi
Department of Urology, Hamamatsu University School of Medicine
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NAITO Takafumi
Division of Hospital Pharmacy, Hamamatsu University School of Medicine
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Kagawa Yoshiyuki
Department Of Pharmacokinetics And Pharmacodynamics And Global Center Of Excellence (coe) And Clinic
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Kagawa Yoshiyuki
Department Of Clinical Pharmaceutics And Pharmacy Practice Faculty Of Pharmaceutical Sciences Univer
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Ozono Seichro
Department Of Urology Hamamatsu University School Of Medicine
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Otsuka Atsushi
Department Of Dermatology Shimane Prefectural Central Hospital
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Ushiyama Tomomi
Department Of Hamamatsu University School Of Medicine
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Ozono Seiichiro
Department Of Hamamatsu University School Of Medicine
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Kawakami Junichi
Department Of Hospital Pharmacy Hamamatsu University School Of Medicine
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Kawakami Junichi
Dep. Of Hospital Pharmacy Hamamatsu Univ. School Of Medicine
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Kagawa Yoshiyuki
Department Of Pharmacokinetics And Pharmacodynamics Global Center Of Excellence (coe) And Clinical P
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Uehara Takashi
Second Department Of Surgery Hamamatsu University School Of Medicine
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Otsuka Atsushi
浜松医科大学 泌尿器科学
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Otsuka Atsushi
Department Of Dermatology Kyoto University
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Mino Yasuaki
Department of Hospital Pharmacy, Hamamatsu University School of Medicine:Department of Clinical Pharmaceutics and Pharmacy Practice, Faculty of Pharmaceutical Sciences, University of Shizuoka
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Kagawa Yoshiyuki
Department of Clinical Pharmaceutics & Pharmacy Practice, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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