Hange-shashin-to Raises Levels of Somatostatin, Motilin, and Gastrin in the Plasma of Healthy Subjects
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概要
- 論文の詳細を見る
Hange-shashin-to has been used for chronic hypofunction of the gastrointestinal tract and to improve functional abnormalities of the upper and lower gastrointestinal system. To determine whether the pharmacological effects of Hange-shashin-to are due to gut-regulatory peptide levels, we developed a sensitive and specific doubleantibody enzyme immunoassay (EIA) for detecting motilin and also examined the levels of somatostatin-, motilin-, gastrin-, and vasoactive intestinal peptide (VIP)-immunoreactive substances (IS) in plasma from healthy subjects. We developed a sensitive (3.5pg, 1.4pg/well) and specific (carboxy-terminal region) EIA for motilin. A single oral administration of Hange-shashin-to 6.0g caused significant increases somatostatin-IS (20-60min), motilin-IS (40min), and gastrin-IS (40-90min) levels in plasma compared with levels in a placebo group. Hange-shashin-to had no significant effect on VIP-IS levels after single administration. These changes in hormone levels (somatostatin, motilin, and gastrin) might relate to normalization of the upper and lower gastrointestinal system by Hange-shashin-to.
- 公益社団法人日本薬学会の論文
- 2002-03-01
著者
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Takeyama M
Department Of Clinical Pharmacy Oita University Hospital
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Itoh Hiroki
Department Of Cardiology Tokyo Women's Medical University
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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NAITO Takafumi
Department of Clinical Pharmacy, Oita Medical University
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Naito T
浜松医科大学 医学部附属病院薬剤部
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NAITO Takafumi
Division of Hospital Pharmacy, Hamamatsu University School of Medicine
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Takeyama M
Oita Univ. Hospital
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YASUNAGA FUMITAKA
Department of Clinical Pharmacy, Oita Medical University
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Nagano Toshiaki
Division Of Hospital Pharmacy Hamamatsu University School Of Medicine
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Yasunaga Fumitaka
Department Of Clinical Pharmacy Oita Medical University
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