Comparison of the Effects of Sho-hange-ka-bukuryo-to and Nichin-to on Human Plasma Adrenocorticotropic Hormone and Cortisol Levels with Continual Stress Exposure(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Sho-hange-ka-bukuryo-to and Nichin-to, traditional Chinese herbal (Kampo) medicines have been used to treat vomiting and nausea. Traditional herbal medicines have frequently been used in the empirical treatment. Some patients who take these medicines have no organic disease but have conditions classified as non-ulcer dyspepsia (NUD). To determine the pharmacological effects of Sho-hange-ka-bukuryo-to, Nichin-to, and the two herbs (Pinelliae Tuber and Zingiberis Rhizoma, both of which are included in Sho-hange-ka-bukuryo-to and Nichin-to), we examined the effects of these medicines on the plasma levels of adrencorticotropic hormone (ACTH) and cortisol under stress conditions by repetitive blood sampling. After a single administration of Kampo medicine or a placebo, venous blood samples were taken before and 20-240 min after administration. A single administration of Sho-hange-ka-bukuryo-to caused significant suppression of an increase in plasma ACTH-immunoreactive substance (IS) levels at 120 to 180 min and tended to suppress increases in plasma cortisol levels at 240 min, compared with the response to a placebo. A single administration of Nichin-to caused significant suppression of increases in plasma ACTH-IS levels at 120 min compared with a placebo group, but had no effect on plasma cortisol levels. Pinelliae Tuber had no significant effects in plasma ACTH-IS or cortisol, but Zingiberis Rhizoma significantly suppressed the increase of ACTH-IS (120 min) and cortisol (180 min). These medicines have a modulatory effect on the hypothalamo-pituitary-adrenal (HPA) axis and autonomic nervous function. These effects might be beneficial in stress-related disease and suggest that this medicine has clinical pharmacological activity.
- 公益社団法人日本薬学会の論文
- 2004-10-01
著者
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Sasano H
Tohoku University 21st Century Coe Program 'comprehensive Research And Education Center For Pla
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Inoue Shin
Department of Internal Medicine, Showa University Dental Hospital
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ITOH Hiroki
Department of Physics, Faculty of Science, Hokkaido University
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TAKEYAMA MASAHARU
Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine
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Takeyama M
Department Of Clinical Pharmacy Oita University Hospital
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Inoue S
Department Of Clinical Pharmacy Oita University Hospital
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Itoh Hiroki
Department Of Cardiology Tokyo Women's Medical University
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Takeyama Masaharu
Department Of Anesthesiology And Critical Care Medicine Kagoshima University School Of Medicine
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SATO Yuhki
Department of Clinical Pharmacy, Oita University Hospital
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KATAGIRI Fumihiko
Department of Clinical Pharmacy, Oita University Hospital
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Takeyama M
Oita Univ. Hospital
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Sato Yuhki
Department Of Clinical Pharmacy Oita University Hospital
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Inoue Shin
Department Of Clinical Pharmacy Oita University Hospital
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Inoue S
Fujisawa Technical Serv. Co. Ltd. Osaka Jpn
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Katagiri Fumihiko
Department Of Clinical Pharmacy Oita University Hospital
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